Effects of Persistent and Bioactive Organic Pollutants on Human Health (eBook)

DAVID O. CARPENTER, MD, is a public health physician. His research focuses on human diseases resulting from exposure to environmental contaminants. Following positions at the National Institute of Mental Health and the Armed Forces Radiobiology Research Institute, Dr. Carpenter joined the New York State Department of Health as Director of the Wadsworth Center for Laboratories and Research. He helped create and became the first Dean of the School of Public Health, a collaborative endeavor of the University at Albany (SUNY) and the New York State Department of Health. Upon stepping down as Dean, Dr. Carpenter founded the Institute for Health and the Environment. In 2011, the Institute was named a Collaborating Centre of the World Health Organization in Environmental Health.

Contributors vii

1. Introduction: Why Should We Care about Organic Chemicals
and Human Health? 1

David O. Carpenter

2. Sources of Human Exposure 8

Martí Nadal and José L. Domingo

3. The Burden of Cancer from Organic Chemicals 26

Molly M. Jacobs, Rachel I. Massey, and Richard W. Clapp

4. Carcinogenicity and Mechanisms of Persistent Organic
Pollutants 57

Gabriele Ludewig, Larry W. Robertson, and Howard P.
Glauert

5. Diabetes and the Metabolic Syndrome 101

Duk-Hee Lee and David R. Jacobs, Jr.

6. Mechanistic Basis for Elevation in Risk of Diabetes Caused
by Persistent Organic Pollutants 130

Jérôme Ruzzin

7. Cardiovascular Disease and Hypertension 143

Marian Pavuk and Nina Dutton

8. Obesity 174

Eveline Dirinck, Adrian Covaci, Luc Van Gaal, and Stijn
Verhulst

9. Effects and Predicted Consequences of Persistent and
Bioactive Organic Pollutants on Thyroid Function 203

Stefanie Giera and R. Thomas Zoeller

10. An Overview of the Effects of Organic Compounds on
Women's Reproductive Health and Birth Outcomes 237

Susan R. Reutman and Juliana W. Meadows

11. Effects of Organic Chemicals on the Male Reproductive
System 315

Lars Rylander and Anna Rignell-Hydbom

12. Effects of Endocrine-Disrupting Substances on Bone and
Joint 332

Chi-Hsien Chen and Yueliang Leon Guo

13. Organic Chemicals and the Immune System 362

David O. Carpenter

14. Exposures to Organic Pollutants and Respiratory Illnesses
in Adults and Children 384

Krassi Rumchev, Jeff Spickett, and Janelle Graham

15. Cognitive Function 400

Lizbeth López-Carrillo and Mariano E. Cebrián

16. Intellectual Developmental Disability Syndromes and
Organic Chemicals 421

David O. Carpenter

17. Mechanisms of the Neurotoxic Actions of Organic Chemicals
448

David O. Carpenter

18. Parkinson's Disease 471

Samuel M. Goldman

19. Psychiatric Effects of Organic Chemical Exposure
514

James S. Brown, Jr.

20. Growth and Development 532

Lawrence M. Schell, Mia V. Gallo, and Kristopher K.
Burnitz

21. How Much Human Disease Is Caused by Exposure to Organic
Chemicals? 557

David O. Carpenter

Index 570