Endothelin and Its Inhibitors

Since its characterisation in 1988, endothelin research has moved very rapidly. Here in this volume are collected reviews that cover, systematically, every area of our knowledge regarding the endothelins. (Endothelin production, actions of endothelins, receptors, signalling pathways, endothelin and diseases, endothelin antagonists, endothelin converting enzyme inhibitors)

1 Historical Perspective and Introduction to the Endothelin Family of Peptides.- 2 Sarafotoxins and Their Relationship to the Endothelin Family of Peptides.- 3 Identity of Endothelin-Converting Enzyme and Other Targets for the Therapeutic Regulation of Endothelin Biosynthesis.- 4 Endothelin Receptors.- 5 Cell Signaling by Endothelin Peptides.- 6 Lessons from Gene Deletion of Endothelin Systems.- 7 Endothelin-Converting Enzyme Inhibitors and their Effects.- 8 Endothelin Converting Enzymes and Endothelin Receptor Localisation in Human Tissues.- 9 Endothelin Receptor Antagonists.- 10 Toxicology of Endothelin Antagonists.- 11 Endothelins and the Release of Autacoids.- 12 The Roles of Endothelins in Proliferation, Apoptosis, and Angiogenesis.- 13 The Involvement of Endothelins in Cerebral Vasospasm and Stroke.- 14 Involvement of the Endothelins in Airway Reactivity and Disease.- 15 Endothelin-1 and Pulmonary Hypertension.- 16 Vascular and Cardiac Effects of Endothelin.- 17 Endothelins Within the Liver and the Gastrointestinal System.- 18 Endothelin and the Kidney.- 19 Endothelin Ligands and their Experimental Effects Within the Human Circulation.