Experimental Lung Cancer

Keynote Address: Progress in Respiratory Carcinogenesis.- Session I Methods in Experimental Respiratory Carcinogenesis and Bioassays. Chairman: S. LASKIN.- Models in Chemical Respiratory Carcinogenesis.- The Role of the Host in the Development of in vivo Models for Carcinogenesis Studies.- The Significance of Aryl Hydrocarbon Hydroxylase Enzyme Systems in the Selection of Model Systems for Respiratory Carcinogenesis.- Pulmonary Carcinogenesis by Two Aryl Hydrocarbons on Three Mouse Strains.- Cell-Mediated Immunity after Intratracheal Exposure to 3-Methylcholanthrene, and its Relationship to Tumor Transplant Growth in C3H/f Mai Mice.- The Influence of Carcinogenic Substances Introduced Intratracheally to Several Generations of Experimental Rats.- Large-Volume Intratracheal Instillation of Particulate Suspensions to Hamsters.- The Intrapleural Route as a Means for Estimating Carcinogenicity.- Localized Submucosal Bronchial Injections of Carcinogens in Dogs.- Studies of Intrabronchial Particle Deposition Using Hollow Bronchial Casts.- The Distribution and Retention of Selected Metals in Rat Tissue after Inhalation of Cadmium Oxide Aerosols.- Conception and Methods of Experimental Studies in Germany to Estimate the Carcinogenic Burden by Air Pollution in Man.- Experimental Carcinogenicity and Bioassays of Automobile Exhaust Condensate and Its Polycyclic Aromatic Hydrocarbons.- Session II Multifactorial Respiratory Carcinogenesis and Related Bioassays. Chairman: P. NETTESHEIM.- Review and Introductory Remarks: Multifactorial Respiratory Carcinogenesis.- Morphogenesis of Experimental Lung Tumors in Hamsters: The Effects of Carrier Dust.- Role of Particles in Respiratory Carcinogenesis Bioassay.- Effect of Particulate Benzo(a)pyrene Carrier on Carcinogenesis in the RespiratoryTract of Hamsters.- Chemical Induction of Lung Carcinomas in Rats.- Synergistic Effects of Benzo(a)pyrene and N-Methyl-N-Nitrosourea on Respiratory Carcinogenesis in Syrian Golden Hamsters.- The Effects of Particulates on Respiratory Carcinogenesis by Diethylnitrosamine.- Respiratory Cocarcinogenesis Studies with Ferric Oxide: A Test Case of Current Experimental Models.- Induction of Pulmonary Tumors in Mice by Oral Administration of a 5-Nitrofuran Derivative.- Surface Morphology of Tracheal Epithelium in Vitamin A Deficiency and Reversal.- Postinfluenzal Pulmonary Lesions in Vitamin A Deficient Mice.- Influenza-Virus-Induced Hyperplasia of. the Respiratory Tract of the Hamster.- Inoculation of Owl Monkeys (Aotus trivirgatus) with 7,12-Dimethylbenz(a)anthracene and Herpesvirus saimiri. Induction of Epidermoid Carcinoma in the Lung.- Session III Bioassays of Respiratory Carcinogens in Tobacco Products. Chairman: W.P. DONTENWILL.- Review and Introductory Remarks: Bioassays of Respiratory Carcinogens in Tobacco Products.- A Modified Method for Locating Labeled Smoke Particles in Organs of Syrian Golden and European Hamsters.- Dotriacontane-16,17-14C Distribution Pattern in the Respiratory System of Two Hamster Species after Passive Exposure to Radioactive Labeled Smoke.- Cigarette Smoke Inhalation Studies in Inbred Syrian Hamsters.- Tumorigenic Effect of Chronic Cigarette Smoke Inhalation on Syrian Golden Hamsters.- Effect of Chronic Exposure to Cigarette Smoke on Tumor Incidence in the Syrian Golden Hamster.- Carcinogenicity of Inhaled Cigarette Smoke in the NMU-Pretreated Hamster Larynx.- Validity of the Sebaceous Gland Test and the Hyperplasia Test for the Prediction of the Carcinogenicity of Cigarette Smoke Condensates and Their Fractions.- Squamous Carcinoma of the Lung from Cigarette Smoke Condensate in Implanted Beeswax Pellets.- Session IV Radiation Carcinogenesis and Bioassays. Chairman: J.F. PARK.- Radiation Carcinogenesis. Introductory Remarks.- The Effects of Inhaled Uranium Mine Air Contaminants in Beagle Dogs.- Lesions and Lung Cancers Induced in Rats by Inhaled Radon 222 at Various Equilibriums with Radon Daughters.- Studies of Pulmonary Carcinogenesis in Rodents Following Inhalation of Transuranic Compounds.- Lung Irradiation with Static Plutonium Microspheres.- Respiratory Carcinogenesis in Rats after Inhalation of Radioactive Aerosols of Actinides and Lanthanides in Various Physicochemical Forms.- Pulmonary Carcinogenesis and Chronic Beta Irradiation of Lung.- Histologic Observations on the Pathogenesis of Lung Cancer in Hamsters Following Administration of Polonium-210.- Cellular Localization of Intratracheally Administered 210Po in the Hamster Lung Using Autoradiography of Thin Sections from Plastic Embedded Tissue.- Experimental Respiratory Carcinogenesis: Interaction between Alpha Radiation and Benzo(a)pyrene in the Hamster.- Session V In vitro Bioassays of Respiratory Carcinogens. Chairman: M.B. SPORN.- Review and Introductory Remarks: The Role of Organ Culture and Cell Culture Methods in Studies of Respiratory Carcinogenesis and Anti-Carcinogenesis.- Interactions between Radiation and Benzo(a)pyrene in an in vitro Model for Malignant Transformation.- Dose Dependence of Carcinogen-Induced Changes in Tracheal Epithelium in Organ Culture.- Topical Application of Polycyclic Hydrocarbons to Differentiated Respiratory Epithelium in Long-Term Organ Cultures.- The Bioassay of Carcinogenesis: Effects on the Epithelial Cell Complement of Rat Tracheae Maintained in vitro.- Effects of Cigarette Smoke Condensate (CSC) on RatFetal Lung in Organ Culture.- Tracheal Grafts.- Studies of Ultrastructure, Cytochemistry, and Organ Culture of Human Bronchial Epithelium.- Studies on Carcinogen Binding in vitro in Isolated Hamster Tracheas.- The Reversal of Keratinized Squamous Metaplastic Lesions of Vitamin A Deficiency in Tracheobronchial Epithelium by Vitamin A and Vitamin A Analogs in Organ Culture: A Model System for Anti-Carcinogenesis Studies.- Transformation of Nonvirus Producing BALB/3T3 Cells by an Environmental Extract.- Concluding Remarks: Progress in Respiratory Carcinogenesis Bioassays.- List of Contributors.