Alcohol and Neurobiology
Crc Press Inc (Verlag)
978-0-8493-7936-9 (ISBN)
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Public attention and research efforts are being driven by an ever- increasing understanding of the problems and magnitude of alcohol abuse, particularly its neurological consequences. Two out of three high school students report that they used alcohol during the previous month. This continuing source of potential abusers, plus 10 million alcohol-abusing adults, along with the several million abusers of other drugs, costs the people of the U.S. more than $200 billion in lost wages, health care, theft, and shortened life span. An intimate, detailed knowledge of the effects of alcohol on the biochemical reactions and neurological changes is critical in preventing or treating abuse. We must study the mechanisms of ethanol's effects on the neurological system at a cellular and systematic level to understand its actions. These include modifications of hormonal regulation and production with major functional consequences. The progress of research over the past decade is encouraging as we begin to summarize and evaluate in detail advances in understanding changes in the biochemistry and physiology caused by ethanol. This information will assist the researcher, clinician, and student in comprehending the complex changes caused by direct and indirect effects of single drugs at the cellular level.
Plasma GABA as a Biological Marker for Alcoholism (Frederick Petty). Ethanol Effects on Central N-Methyl-d-Aspartate Receptors (Laura C. Daniell). Ethanol and Agonist-Induced Desensitization of the GABA Receptor (Gerald D. Frye and Joy Mathew). The GABA-A Receptor Complex in Alcohol Dependence (Richard W. Olsen, Norio Kokka, and Douglas W. Sapp). Differential Sensitivity of Nigrotectal GABA Neurons to Alcohol Withdrawal Seizures (Joanna Peris). Reduction of Anxiety by Ethanol in Animal Models: Relation to the GABA/Benzodiazepine-Receptor Chloride-Channel Complex (Hugh E. Criswell and George R. Breese). The Function of Brain Dopamine in Ethanol Reinforcement (Herman H. Samson). Alcohol and the Voltage-Dependent Calcium Channel (Mark H. Hawthorn). Insights into the Molecular Mechanism of Action of Ethanol on Brain Calcium Channels and Muscarinic Acetylcholine Receptors Derived from Long- and Short-Sleep Mice (Joseph J. McArdle, Simon P. Aiken, Jay J. Choi, Guo-Jie Huang, Xue Ming, Elizabeth N. Shafik, Leonidas Tsiokas, Simi Vincent, Shan Zhang, and Mark Watson). Ethanol, Calcium Channels, and Intracellular Calcium in Cultured Neural Cells (David A. Greenberg and Jane Chan). Membrane Exofacial and Cytofacial Leaflets: A New Approach to Understanding How Ethanol Alters Brain Membranes (W. Gibson Wood and Friedhelm Schroeder). Adaptation of Neuronal Cell Membranes to Chronic Alcohol Consumption (Hagai Rottenberg). Domain-Specific Binding of Alcohols to Neuronal Membranes (James G. Stout and George P. Kreishman). Effects of Ethanol on Crayfish Behavior and Synaptic Transmission (Jay A. Blundon). Effects of Ethanol on Membrane Lipids (Elizabeth S. Rowe). Effects of Ethanol on Neuronal Voltage-Gated Ion Channels (Vellareddy Anantharam and Steven N. Treistman).
336 pp., 6 x 9, due July 1992, ISBN 0-8493-7936-9.
| Erscheint lt. Verlag | 24.6.1992 |
|---|---|
| Reihe/Serie | Physiology of Substance Abuse ; 4 |
| Zusatzinfo | 5 Tables, black and white |
| Verlagsort | Bosa Roca |
| Sprache | englisch |
| Maße | 156 x 235 mm |
| Gewicht | 680 g |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Neurologie |
| Studium ► 2. Studienabschnitt (Klinik) ► Pharmakologie / Toxikologie | |
| ISBN-10 | 0-8493-7936-9 / 0849379369 |
| ISBN-13 | 978-0-8493-7936-9 / 9780849379369 |
| Zustand | Neuware |
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