Diabetes Mellitus

;; Part I: Insulin Secretion 1. Kinetics of Insulin Secretion: Underlying Metabolic Events 2. Insulin Gene Regulation 3. Processing of the Insulin Molecule 4. The Role of Glucose Transport and Phosphorylation in Glucose-Stimulated Insulin Secretion 5. Electrophysiology of the Pancreatic -Cell 6. Sulfonylurea Receptors, ATP-Sensitive Potassium Channels, and Insulin Secretion 7. GTP-Binding Proteins in the Regulation of Pancreatic -Cell Function 8. Insulinotropic Glucagon-Like Peptides 9. Insulin Secretion in Humans: Physiologic Regulation and Alterations in Disease States 10. Detrimental Effects of Chronic Hyperglycemia on the Pancreatic -Cell 11. Glucose Toxicity of the -Cell: Cellular and Molecular Mechanisms 12. Lipotoxity 13. Islet Amyloid and Its Potential Role in the Pathogenesis of Type 2 Diabetes Mellitus Part II: Insulin Action 14. Physiologic Action of Insulin 15. Interaction of Some Biochemical and Physiologic Effects of Insulin that May Play a Role in the Control of Blood Glucose Concentration 16. Glucose Counterregulatory Hormones: Physiology, Pathophysiology, and Relevance to Clinical Hypoglycemia 17. The Biochemistry of Insulin Action 18. The Insulin Receptor 19. Insulin Receptor Substrate Proteins Mediate Common Signaling Pathways for Insulin Action and -Cell Function 20. Regulation of Insulin Action by Protein-Tyrosine Phosphatases 21. Small GTPases and (Serine/Threonine) Protein Kinase Cascades in Insulin Signal Transduction 22. Protein Kinase C 23. Regulation of Glycogen Synthesis 24. Insulin Action on Glucose Transport 25. Vesicular Trafficking and GLUT4 Translocation 26. Hormone-Sensitive Lipase, Perilipins, and the Control of Lipolysis in Adipocytes 27. A Role For Phosphodiesterase 3B in the Antilipolytic Action of Insulin 28. Gene Regulation 29. Insulin and Intracellular Ions 30. Insulin Degradation 31. Germline Manipulation of Glucose Transport and Glucose Homeostasis Part III: Definition and Classification 32. Definition and Classification of Diabetes Mellitus and the New Criteria for Diagnosis Part IV: Type 1 Diabetes Mellitus 33. Diabetic Ketoacidosis and the Hyperglycemic Hyperosmolar Syndrome 34. The Natural History of Autoimmunity in Type 1A Diabetes Mellitus 35. Humoral Autoimmunity 36. Autoantibodies and the Disease Process of Type 1 Diabetes Mellitus 37. Roles of Cell-Mediated Immunity and Cytokines in the Pathogenesis of Type 1 Diabetes Mellitus 38. Major Histocompatibility Locus and Other Genes That Determine the Risk of Development of Type 1 Diabetes Mellitus 39. Association Between Immune-Mediated (Type 1) Diabetes Mellitus and Other Autoimmune Diseases 40. Role of Viruses in the Pathogenesis of Type 1 Diabetes Mellitus 41. Animal Models of Autoimmune Diabetes Mellitus 42. Insights From Transgenic and Gene Targeting Strategies in Type 1 Diabetes Mellitus Part V: Therapeutics for Type 1 Diabetes Mellitus 43. The Treatment of Diabetes Mellitus to Prevent and Delay Long-Term Complications: The Diab