Mosaicism in Human Skin

Understanding Nevi, Nevoid Skin Disorders, and Cutaneous Neoplasia

(Autor)

Buch | Hardcover
XIII, 229 Seiten
2013 | 2014
Springer Berlin (Verlag)
978-3-642-38764-7 (ISBN)
149,79 inkl. MwSt
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This book presents an overview on the strikingly manifold patterns and peculiarities of mosaic skin disorders. It will help dermatologists understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome.
Mosaicism is a powerful biologic concept, originally developed from studying plants and animals. All cutaneous neoplasms, both benign and malignant, reflect mosaicism, which is the necessary basis to explain numerous human skin disorders. For example, various mosaic patterns visualize the embryonic development of human skin and X-linked skin disorders explain why women live longer than men, and so on. This book presents, for the first time, a comprehensive overview on the strikingly manifold patterns and peculiarities of mosaic skin disorders. This reader-friendly structured and straightforward publication will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome.

PATTERNS AND MECHANISMS: Mosaicism as a Biological Concept:.- History.- Mosaicism in Plants, Animals, Humans.- Mosaicism Versus Chimerism.- The Mechanisms of Mosaicism .- Genomic Mosaicism of Autosomes.- Epigenetic Mosaicism of autosomes.- Genomic Mosaicism of X Chromosomes.- Epigenetic Mosaicism of X Chromosomes.- The patterns of Mosaicism .- Lines of Blaschko.- Checkerboard Pattern.- Phylloid Pattern.- Patchy Pattern Without Midline Separation.- Lateralization.- Other Patterns, so far Unclassifiable.- MOSAIC SKIN DISORDERS: Nevi.- Melanocytic Nevi.- Other Forms of Pigmentary Mosaicism.- Epidermal Nevi.- Vascular Nevi.- Connective Tissue Nevi.- Nevoid Skin Disorders.- Lyonization (Functional X-Chromosome Mosaicism) in X-Linked Skin Disorders.- Autosomal Non-Nevi.- Neoplastic Skin Lesions.- Benign Tumors.- Malignant Tumors.- CONCLUSION.

Erscheint lt. Verlag 6.1.2014
Zusatzinfo XIII, 229 p. 232 illus., 208 illus. in color.
Verlagsort Berlin
Sprache englisch
Maße 178 x 254 mm
Gewicht 763 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Augenheilkunde
Medizin / Pharmazie Medizinische Fachgebiete Dermatologie
Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Medizin / Pharmazie Medizinische Fachgebiete Pädiatrie
Studium 2. Studienabschnitt (Klinik) Humangenetik
Schlagworte Dermatologie • Dermatologie / Hautkrankheiten • Genetics • Lethal mutations • Lines of Blaschko • Nevi • skin disorders
ISBN-10 3-642-38764-0 / 3642387640
ISBN-13 978-3-642-38764-7 / 9783642387647
Zustand Neuware
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