Blood and Marrow Transplantation Long Term Management – Prevention and Complications

Edited by Bipin N Savani Professor of Medicine, Director, Long Term Transplant Clinic, Hematology and Stem Cell Transplantation Section, Vanderbilt University Medical Center, Nashville, TN, USA

Foreword by John Barrett vii Foreword by Stephanie J Lee viii Foreword by John Goldman ix List of Contributors x Section 1 Late effects concepts 1 1 Introduction 3 Bipin N Savani 2 Overview: transplant data and increasing numbers of long-term survivors 7 Jakob R Passweg and Helen Baldomero 3 Long-term transplant clinic setup 11 Andre Tichelli, Joerg P Halter, Jakob R Passweg, and Alicia Rovo 4 Late effects after allogeneic hematopoietic stem cell transplantation 21 Shahrukh Hashmi and Mark R Litzow 5 Late effects after autologous hematopoietic stem cell transplantation 31 Sairah Ahmed and Yago Nieto 6 Graft-versus-host disease and late effects after hematopoetic stem cell transplantation 43 Gerard Socie 7 Prominent role of allied health professionals (nurse practitioners, physician assistants, others) in long-term follow-up after hematopoietic stem cell transplantation 52 Catherine E Lucid Section 2 Management, 55 8 Screening and prevention guidelines for hematopoietic cell transplant survivors 57 Navneet S Majhail and J Douglas Rizzo 9 Secondary malignancies: prevalence, screening, prevention, and management guidelines 65 Paolo F Caimi and Hillard M Lazarus 10 Cutaneous chronic graft-versus-host disease 77 Attilio Olivieri, Daniela Massi, Andrea Bacigalupo, and Anna Campanati 11 Anti-infective prophylaxis, immunization and prevention of recurrent infectious complications in long-term survivors 106 John P Galvin and Jayesh Mehta 12 Seasonal virus infections: prevention and management guidelines 116 Gaurav Trikha and John R Wingard 13 Exposure to family members: infections and recent live vaccinations 130 Brian G Engelhardt and James E Crowe, Jr 14 Late pulmonary complications after allogeneic hematopietic stem cell transplantion: bronchiolitis obliterans syndrome (BOS) and organizing pneumonia (OP) 141 Lee Gazourian, Gerald L Weinhouse, Joseph H Antin, and Vincent T Ho 15 Post-transplantation bone disease: prevalence, monitoring, prevention, and management guidelines 151 Kathryn Dahir, Brandon Perry, and Shubhada Jagasia 16 Ocular complications: prevalence, monitoring, prevention, and management guidelines 162 Andre Tichelli and Alicia Rovo 17 Oral complications in hematopoietic stem cell transplantation survivorship 172 Sharon Elad, Corey Cutler, and Nathaniel Treister 18 Sexual dysfunction in long-term survivors: monitoring and management 183 Andrea L Utz and Shubhada Jagasia 19 Fertility issues, contraception, and pregnancy outcome in long-term survivors 193 Alicia Rovo, Nina Salooja, Carl P Schwarze, Joerg P Halter, and Andre Tichelli 20 Follow-up of children after hematopoietic stem cell transplantation: growth and development 203 Kristina K Hardy, David A Jacobsohn, and Evelio Perez-Albuerne 21 Posttransplant diabetes mellitus: monitoring, prevention, and management guidelines 215 Prathima Jasti, Shichun Bao, and Shubhada Jagasia 22 Thyroid disease: monitoring and management guidelines 225 M Kathleen Figaro, Cheryl A Fassler, Shubhada Jagasia, and Vipul T Lakhani 23 Special issues related to female long-term survivors 233 Melissa A Merideth, Kristin Clay Chabarria, Tajana Klepac Pulanic, and Pamela Stratton 24 Cardiac and vascular complications in long-term survivors after hematopoietic stem cell transplantation 244 Alicia Rovo and Andre Tichelli 25 Hyperlipidemia: prevalence, monitoring, management, interactions with immunosuppressive agents, and follow-up 258 Dara L Eckerle Mize, Shubhada Jagasia, and Jeffrey B Boord 26 Hypertension management in long-term survivors 269 Imad Abboud 27 Gastrointestinal complications of hematopoietic cell transplantation 276 Preet Bagi, Niharika Samala, Steven Pavletic, and Theo Heller 28 Hepatic complications of hematopoietic stem cell transplantation 286 Niharika Samala, Preet Bagi, Theo Heller, and Steven Pavletic 29 Monitoring and management of hepatitis B, hepatitis C, and HIV infection before and after transplantation 294 Keith Luckett and Stephen Dummer 30 Prevention and management of renal complications in long-term survivors 304 Michael Dickenmann and Joerg P Halter 31 Immunosuppressive agents and monitoring in long-term survivors 314 Paul Shaughnessy and Helen Leather Section 3 Supportive care for long-term survivors after HSCT 321 32 Nutritional assessments and nutritional supplementation for long-term transplant survivors: multivitamins, vitamin D, calcium, antioxidants, and minerals 323 Lauren Zatarain, LaQuisa Hill, Daniel R Thomas, and Stacey A Goodman 33 Daily routines and guidelines: driving, infection isolation, masks, food/diet, activities, exercise, pets, sun exposures, and others 332 Angela M Woods 34 Caregivers of long-term survivors 340 Elizabeth Wulff-Burchfield 35 Health-related quality of life in adult and pediatric survivors of hematopoietic stem cell transplantation 345 Margaret Bevans and Lori Wiener 36 Prevalent psychosocial adjustment issues and solutions: lifestyle and social challenges 368 Katrina M Stokes 37 A patient s perspective: concepts of long-term survivor support groups and their roles 376 Michael W Brown APPENDIX 1 NMDP/Be The Match posttransplant guidelines resources 379 Darlene Haven APPENDIX 2 Long-term follow-up calendar 381 Andre Tichelli, Joerg P Halter, Jakob R Passweg, and Alicia Rovo APPENDIX 3 Commonly used transplant-related medications in long-term survivors 385 Melissa Logue Index, 387