Aerosols in Medicine

Part 1 Upper Airway - Structure, Function and Therapy (N. Mygind): Introduction. Anatomy of the nose. Applied physiology of the nose. Pathology of rhinitis. Aerosol therapy in the nose. Pharynx and larynx. References. Part 2 Lower Airway - Structure and Function (J.B. Forrest): Introduction. General organization of lung structure. Acknowledgements. References. Part 3 Aerosol Characterization and Generation (D.L. Swift): Characteristics of aerosols. Aerosol generation. References. Part 4 Airflow Dynamics in the Human Airways (H.K. Chang, A.S. Menon): Introduction. Airway models. Flow in the large airways (trachea, main and lobar bronchi). Flow in the upper airways (nose, nasopharynx, mouth, oropharynx, pharynx and anterior larynx). Relevance of fluid dynamics to particle deposition. References. Part 5 Mechanisms of Particle Deposition and Clearance (J.D. Brain, J.D. Blanchard): Introduction. Particle transport and deposition mechanisms. Characterizing and delivering therapeutic aerosol. Factors influencing particle deposition. Selecting deposition patterns. Clearance and retention of particles. Cough. Measuring particle retention. Conclusions. References. Part 6 Models of Aerosol Behaviour in Airways and Alveoli (P.E. Morrow, C.P. Yu): Introduction. Particle deposition. Particle removal from the respiratory system. Acknowledgement. References. Part 7 Aerosols in Diagnosis - Ventilation, Airway Penetrance, Epithelial Permeability, Mucociliary Transport and Airway Responsiveness (M.B. Dolovich, D.W. Cockcroft, G. Coates): Introduction. Aerosols and the assessment of ventilation. Aerosol "penetrance" in the assessment of airway obstruction. Aerosol and airway pharmacological responses. Aerosols in the assessment of pulmonary epithelial permeability. Aerosols in the assessment of mucociliary transport. Use of aerosols in assessment of airway responsiveness. Acknowledgement. References. Part 8 Epithelial Permeability (R.M. Effros): Introduction. Correlation of structure and permeability. Indicator properties which affect transport. Reflection coefficients of the pulmonary epithelium. Radioaerosol studies. Active transport across the pulmonary epithelium. Clinical applications of radioaerosol clearance. References. Part 9 Airway Mucus Clearance and Mucociliary Transport (P. Camner, B. Mossberg): Introduction. Basic data. Importance of mucociliary clearance. Lung diseases. Interventions. Environmental factors. References. Part 10 Bronchial Asthma, Chronic Bronchitis and Pulmonary Parenchymal Diseases (0. Selroos): Introduction. Drugs for inhalation. Delivery systems. Clinical indications. References. Part 11 Pulmonary Infections (C. Breese Hall, J.T. McBride): Introduction. Aerosolised antibacterial agents. Aerosolised chemoprophylactic therapy for Pneumocystis carinii. Aerosolised antiviral agents. Environmental agents. Summary. References. (Part contents).