Prion Diseases

Pathogenesis of Prion Diseases.- Prions: from neurografts to neuroinvasion.- Follicular dendritic cells in scrapie pathogenesis.- Cellular and sub-cellular localisation of PrP in the lymphoreticular system of mice and sheep.- Pharmacological manipulation of early PrPres accumulation in the spleen of scrapie-infected mice.- Pathogenesis of natural scrapie in sheep.- Animal Models for Priorn Diseases.- Detection of cattle-derived BSE prions using transgenic mice overexpressing bovine PrPC.- Analyzing the influence of PrP primary structure on prion pathogenesis in transgenic mice.- A single amino acid alteration in murine PrP dramatically alters TSE incubation time.- A transgenic model of a familial prion disease.- Transgenic models of prion disease.- Epidemiology and Diagnosis of Prion Diseases.- Surveillance of BSE.- Histopathology and immunohistochemistry of human transmissible spongiform encephalopathies (TSEs).- Pathology of variant Creutzfeldt-Jakob disease.- Clinical and differential diagnosis of Creutzfeldt-Jakob disease.- Putting prions into focus: application of single molecule detection to the diagnosis of prion diseases.- Detection of PrPSc in subclinical BSE with the paraffin-embedded tissue (PET) blot.- Sheep and goats: natural and experimental TSEs and factors influencing incidence of disease.- Application of Prionics Western blotting procedure to screen for BSE in cattle regularly slaughtered at Swiss abattoirs.- Specific determination of the proteinase K-resistant form of the prion protein using two-site immunometric assays. Application to the post-mortem diagnosis of BSE.- Characterization of the Infectious Agent.- PrPSc typing by N-terminal sequencing and mass spectrometry.- Characterization of BSE and scrapie strains/isolates.- Quantitative traits of prion strains are enciphered in the conformation of the prion protein.- Structure and Function of PrP.- Function of PrPc as a copper-binding protein at the synapse.- The prion protein globular domain and disease-related mutants studied by molecular dynamics simulations.- Neurotoxicity but not infectivity of prion proteins can be induced reversibly in vitro.- PrP Conversion.- Inhibition of formation of protease-resistant prion protein by Trypan Blue, Sirius Red and other Congo Red analogs.- The use of monoclonal antibody epitopes for tagging PrP in conversion experiments.- Listed in Current Contents.