Free Radicals in the Pathogenesis of Liver Injury

Section Headings and Selected Papers: Section One: Oxidative Stress and Hepatocyte Damage. Lipid peroxidation and antioxidant systems in the liver injury induced by glutathione depleting agents, A F Casini et al. Effects of free radicals on hormonally- and non-hormonally-regulated calcium homeostasis in rat liver microsomes and hepatocytes, F B Pruijn & A Bast. S;icidal inactivation of haem by halothane, M Manno. Section Two: Free Radicals and Liver Cancer. Genotoxic effects of 4-hydroxyalkenals, P Eckle & H Esterba;er. Evaluation of methylglyoxal genotoxicity in the rat using the micronucleus assay in liver and bone-marrow cells, A Martelli et al. Possible role of free radicals in liver regeneration, L Lambotte et al. Section Three: Free Radicals in Chronic Liver Diseases. Free radical-related liver mitochondrial damage following experimental chronic iron overload, H Rouach et al. Role of free radicals in ethanol-induced acute hepatotoxicity, M Younes & O Strubel;. The role of lipid peroxidation and antioxidants in alcoholic liver disease in man, S Moscarella et al. Section Four: Antioxidant Defences in Liver Injury. Calcium and oxidative stress in the hepatocyte model for cell injury, D J Reed & C E Thoma;. Antioxidant effects of ascorbate and glutathione in microsomal lipid peroxidation are dependent on vitamin E, H Wefers & G Sies. A;tioxidant status in alcoholic liver disease, R J Ward et al. 800 lit. refs. approx., 2 halftones, 99 line drawings