Lithium Effects on Granulopoiesis and Immune Function

Section I: Introduction.- Lithium carbonate in medicine and psychiatry.- Biology of the lithium ion.- Release of vitamin binding proteins from granulocytes by lithium: Vitamin B12 and folate binding proteins.- Section II: Mechanisms of Lithium-Induced Granulocytosis.- The effect of lithium on release of granulocyte colony stimulating activity invitro.- The effect of lithium upon granulocyte production invitro and invivoin the mouse.- Effect of lithium on colony formation and production of colony-stimulating factor.- Myelopoietic modulation by lithium: invitro experiments on its mechanisms of action in man.- Oral lithium carbonate increases colony stimulating activity production from human mononuclear cells.- Effects of lithium chloride on human and murine marrow myeloid colony formation and colony stimulating activity.- Section III: Animal Models.- Lithium effects on granulopoiesis in mice following cytotoxic chemotherapy.- Lithium carbonate enhances granulopoiesis and attenuates cyclophosphamide-induced injury in the dog.- Lithium treatment of cyclic hematopoiesis in the gray collie.- Section IV: Lithium Attenuation of Anti-Cancer Chemotherapy.- Clinical investigation of lithium therapy in acute leukemia.- Lithium and granulocytopenia during induction therapy of acute myelogenous leukemia: update of an ongoing trial.- A placebo controlled study of a seven day course of lithium carbonate following myelotoxic chemotherapy.- The effect of lithium carbonate administration in patients with advanced small cell bronchogenic carcinoma receiving combination chemotherapy and radiotherapy.- Higher leukocyte nadirs with lithium carbonate after chemotherapy.- Prevention by using lithium carbonate of neutropenia due to antiblastics.- A seven year laboratory and clinical experience with lithium carbonate as an adjuvant to cancer chemotherapy.- Lithium attenuation of chemotherapy-induced granulocytopenia: Statistical and clinical significance?.- Section V: Lithium Therapy of Neutropenic Disorders.- In vivo and invitro effects of lithium on granulopoiesis in human neutropenic disorders.- Stimulation of granulopoiesis in vitro and invivo using lithium in children with chronic neutropenia.- Clinical experience with lithium in aplastic anemia and congenital neutropenia.- Lithium therapy of chronic neutropenia.- Lithium carbonate therapy of aplastic anemia.- Section VI: Neutrophil Function in the Presence of Lithium.- Granulocyte function in patients receiving lithium carbonate.- Inhibition of granulocyte adherence by lithium: Possible relationship to lithium-induced leukocytosis.- Effects of lithium on polymorphonuclear leukocyte chemotaxis.- Effects of lithium on neutrophil metabolism invitro and on neutrophil function during therapy.- The bactericidal defect of neutrophil function with lithium therapy.- Effect of lithium on acute myelocytic leukemia cells in tissue culture — A preliminary study.- Drinking water lithium levels fail to predict for the incidences of acute or chronic granulocytic leukemia.- Section VII: Immunologic Effects of Lithium.- Adjuvant-like effects of lithium on peripheral blood mononuclear cells.- Characterization of lithium effects on two aspects of T-cell function.- Anti-suppressor cell effects of lithium invitro and invivo.- Lithium and immune function in man.