Mathematical Modeling in Experimental Nutrition: Vitamins, Proteins, Methods

Dr. Coburn is director of the Biochemistry Department and Clincial Laboratory at the Fort Wayne State Developmental Center and professor ofchemistry at Indiana University–Purdue University at Fort Wayne. His undergraduate training was in agriculture at Rutgers University and his graduate training was in biochemistry at Purdue University. He is a diplomat of the American Board of Clinical Chemistry. His research has focused on the use of stable and radioactive tracers to evaluate the routes, rates, and regulation of vitamin B-6 metabolism. He has published numerous articles and reviews as well as a monograph, Chemistry and Metabolismof 4'-Deoxypyridoxine (CRC Press, 1981).

Vitamin Metabolism: M.H. Green and J.B. Green, Quantitative and Conceptual Contributions of Mathematical Modeling to Current Views on Vitamin A Metabolism, Biochemistry, and Nutrition. J.A. Novotny, L.A. Zech, H.C. Furr, S.R. Dieker, and A.J. Clifford, Mathematical Modeling in Nutrition: Constructing a Physiologic Compartmental Model of the Dynamics of Beta-Carotene Metabolism. J.E. Swanson, K.J. Goodman, R.S. Parker, and Y.-y. Wang, Experimental Approaches to the Study of Beta-Carotene Metabolism: Potential of a 13C Tracer Approach to Modeling Beta-Carotene Kinetics in Humans. J.F. Gregory, III, and K.C. Scott, Modeling of Folate Metabolism. B.-F. Lin, J.-S. Kim, J.-C. Hsu, C. Osborne, K.Lowe, T. Garrow, and B. Shane, Molecular Biology in Nutrition Research: Modeling of Folate Metabolism. S.P. Coburn, Modeling Vitamin B6 Metabolism. Protein and Amino Acid Metabolism: R.J. Beynon, C. Bartram, A. Flannery, R.P. Evershed,P. Hopkins, V. Toescu, J. Phoenix, and R.H.T. Edwards, Interrelationships between Metabolism of Glycogen Phosphorylase and Pyridoxal Phosphate: Implications in McArdle's Disease. D. Hanes, L. Zech, J. Murrell, and M.D. Benson, Metabolism of Normal and Met30 Transthyretin. M.J. Gahl, T.D. Crenshaw, N.J. Benevenga, and M.D. Finke, Use of a Four Parameter Logistic Equation and Parameter Sharing to Evaluate Animal Responses to Graded Levels of Nitrogen or Amino Acids. Energy Metabolism: W.W. Wong, Total Energy Expenditure of Free-Living Humans Can Be Estimated with the Doubly Labeled Water Method. Methods for Obtaining Kinetic Data: E.M. Janle and P.T. Kissinger, Microdialysis and Ultrafiltration. P. Proulx, Membrane Vesicles. J.D. Turner, A. Delaquis, and C. Malo, Culture of Mammary Tissue: Glucose Transport Processes. Simulating Complex Metabolic Processes: L.P. Mercer and D.S. Kelley, Analysis of Bioperiodicity in Physiological Responses. A.R. Shultz, Nutrient–Response: A"Top Down"Approach to Metabolic Control. R.B. King, Modeling Membrane Transport. Computational Aspects of Modeling: W.F. Beltz, Estimation and Use of Kinetic Parameter Distribution in Metabolism and Nutrition. R.C. Boston, T. McNabb, P.C. Greif, and L.A. Zech, Essential Numerical Supports for Kinetic Modeling Software: Linear Integrators. J.A. Jacquez, Indentifiability. S.I. Sayegh, Dynamic Systems and Neural Networks: Modeling in Physiology and Medicine. H. Zhang and Z. Zhang, Graph Theoretical Methods for Physiologically Based Modeling. Chapter References. Index