Bioassay Methods in Natural Product Research and Drug Development -

Bioassay Methods in Natural Product Research and Drug Development

Lars Bohlin, Jan G. Bruhn (Herausgeber)

Buch | Softcover
203 Seiten
2012 | Softcover reprint of the original 1st ed. 1999
Springer (Verlag)
978-94-010-6019-6 (ISBN)
235,39 inkl. MwSt
Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden.
In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery.
Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time.
This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

Plant Biodiversity — Evolutionary and Ecological Perspectives.- Chemodiversity and the Biological Role of Secondary Metabolites, Some Thoughts for Selecting Plant Material for Drug Development.- Evolving Strategies for the Selection, Dereplication and Prioritization of Antitumor and HIV-Inhibitory Natural Products Extracts.- Screening Methods for Detection and Evaluation of Biological Activities of Plant Preparations.- The Use of Receptor Binding, a Very Specific, High Capacity Screening Method, in the Identification of Biologically Active Components from Natural Sources.- Biological and Chemical Evaluation of Plant Extracts and Subsequent Isolation Strategy.- Natural Products with Antiprotozoal Activity.- In-Vitro Assays for Activity-Guided Enrichment of Immunomodulatory Plant Constituents.- Search for Potent Immunomodulatory Agents from Plants and Other Sources.- Cyclooxygenase and 5-Lipoxygenase as Targets for Medicinal Plant Research.- Natural Products in Drug Discovery and Development.- QPRI’s System for Screening of Natural Products.- Phytera’s Strategy for the Discovery of Novel Anti-Infective Agents from Plant Cell Cultures.- Expediting Drug Development Through the Use of Plants.- The Future Role of Natural Products in Drug Discovery.

Reihe/Serie Proceedings of the Phytochemical Society of Europe ; 43
Zusatzinfo X, 203 p.
Verlagsort Dordrecht
Sprache englisch
Maße 160 x 240 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pflege
Medizin / Pharmazie Pharmazie PTA / PKA
Naturwissenschaften Biologie Botanik
Naturwissenschaften Chemie Organische Chemie
ISBN-10 94-010-6019-3 / 9401060193
ISBN-13 978-94-010-6019-6 / 9789401060196
Zustand Neuware
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