Paroxysmal Nocturnal Hemoglobinuria and Related Disorders

1: Overview of Paroxysmal Nocturnal Hemoglobinuria.- Overview of Paroxysmal Nocturnal Hemoglobinuria: Molecular Genetics.- An Overview of the Development of Specific Inhibitors of Complement: Opportunities for Therapy of Paroxysmal Nocturnal Hemoglobinuria.- 2: Pathogenesis and Animal Models of PNH.- Mice with Blood Cells Deficient in GPI-linked Proteins — The Generation of a Murine Model to Investigate the Pathogenesis and Pathophysiology of Paroxysmal Nocturnal Hemoglobinuria (PNH).- A Multistep Model for the Pathogenesis and Evolution of PNH.- Proposals for Classification of the Clinical Stages, Grading of Severity and the Molecular Pathogenesis of Paroxysmal Nocturnal Hemoglobinuria.- 3: Clinical Pathology and Natural History of PNH.- A Short History of Paroxysmal Nocturnal Hemoglobinuria: How We Came To Understand Its Natural History.- Clinical Pathology and Natural History of PNH; The French Society of Hematology Experience.- 4: Mechanism of Clonal Expansion in PNH.- PNH Clone Acquires both a Survival and a Growth Advantage?.- The Role of Lymphoid Cells in the Pathogenesis of PNH.- A Possible Intrinsic Mechanism for Clonal Expansion of PNH Abnormal Cells.- 5: PNH Clones Under Bone Marrow Failure.- Clinical Significance of Increased PNH-Type Cells in the Peripheral Blood of Patients with Aplastic Anemia and Refractory Anemia.- Incidence and Clinical Significance of PNH Clone in Myelodysplastic Syndromes.- The Enigma of the Aplastic Anemia/PNH Syndrome.- 6: PNH, Aplastic Anemia, Myelodysplastic Syndromes (1): Pathology.- Does PNH Ever Arise De Novo?.- Telomeres in Myelodysplastic Syndrome and Its Related Disorders: Does Telomere Length Reflect Stem Cell Turnover in Clonal Hematopoietic Disorders?.- Immunosuppression in Aplastic Anemia.- 7: PNH, Aplastic Anemia,Myelodysplastic Syndromes (2): Clinical Aspects.- Myelodysplastic Syndrome, Acute Leukemia and PNH After Immunosuppressive Therapy for Severe Aplastic Anemia.- Hemopoietic Stem Cell Transplantation (HSCT) for Paroxysmal Nocturnal Hemoglobinuria (PNH) and Acquired Severe Aplastic Anemia (SAA): A Report from the SAA Working Party of the European Blood and Marrow Transplant Group (EBMT).- 8: Related Topics.- Mutation Analysis of PIG-A Gene in Korean Patients with Paroxysmal Nocturnal Hemoglobinuria.- Two Possible Mechanisms for Escape of GPI Cells from the Immunological Attack.- Nature of PNH Clones in Aplastic Anemia.- Serial Analysis of Clonal Expansion in PNH by Flow Cytometry.- The Clinical Course of PNH in the USA and in Japan.- Long-Term Support of Human Hematopoiesis by a Single Stem Cell Clone.- Inflammatory Defects Caused by GPI-Anchor Deficiency in Macrophages.- Paroxysmal Nocturnal Hemoglobinuria in Association with Chronic Myelofibrosis.- Glycosyl-Phosphatidyl-Inositol Anchored Protein-Deficient Blood Cells in Children with Aplastic Anemia.- Helper T Cell Subsets and Th 1/2 Balance in Aplastic Anemia.- Relationship Between Immunologic Abnormalities and Paroxysmal Nocturnal Hemoglobinuria-Associated Clones in Myelodysplastic Syndromes.- Repeated Response to Antithymocyte Globulin in a Case of Aplastic Anemia-Paroxysmal Nocturnal Hemoglobinuria Syndrome.- Treatment of PNH Hemolytic Crisis with Heparin or Low-Molecular Weight Heparin by Its Dual (Anti-Complement and Anti-Coagulant) Activity.- A Patient with Paroxysmal Nocturnal Hemoglobinuria in Whom G-CSF Administration Was Remarkably Effective Against Recurrent Gastrointestinal Infections and Hemolytic Episodes Caused by Cellular Immunodeficiency.- Key Word Index.