Immunobiology of Organ Transplantation

1. Introduction and Overview.- 2. Immunity of Allograft Rejection: An Overview.- 3. MHC: Structure and Function.- 4. HLA Immunogenetics and Transplantation.- 5. Extracellular Processing of MHC Class I Antigens.- 6. Genetics of CD1 Molecules.- 7. Minor Histocompatibility Antigens: Molecular Barriers for Successful Tissue Transplantation.- 8. Mechanisms of AUorecognition.- 9. Complement System in AUorecognition and Rejection of Organ Transplants.- 10. Xenotransplantation.- 11. Conceptual Models in Immunity/Tolerance: Application to Transplantation.- 12. Dendritic Cells in Transplantation: Origin, Immune Activation, and Allograft Tolerance.- 13. Monocytes and Macrophages in Transplantation.- 14. Role of B Lymphocytes and Alloantibodies in Organ Transplantation.- 15. Overview of T-Cell Phenotype and Function.- 16. Costimulatory Molecules in T-Cell Activation and Transplantation.- 17. Regulatory T Cells: Professional Suppressor Cells.- 18. Cytotoxic T Lymphocytes: Mechanism of Action and Role in Allograft Rejection.- 19. Natural Killer Cells in Transplantation: Friends or Foes?.- 20. Natural Killer T (NKT) Cells in Transplantation.- 21. Immunologic Tolerance as Taught by Allografts.- 22. The Immunobiology of Post-Transplant Lymphoproliferative Disorders (PTLD).- 23. Overview of Cytokine Structure and Function.- 24. Chemokines and Transplantation.- 25. Interaction of Innate and Acquired Immune Response: Toll Receptors—Potential Link of Infection to Rejection.- 26. Nitric Oxide, Oxygen Radicals.- 27. The Role of Neutrophils in Transplantation.- 28. Heme Oxygenase-1 and Transplantation.- 29. The Heat Shock Response and Transplantation Immunology.- 30. The Role of Ischemia Reperfusion Injury in Graft Rejection.- 31. Extracellular Matrix and Organ Transplantation.- 32. Endothelial Cell Biology: Inflammatory Biomarkers and Risk of Transplant Atherosclerosis.- 33. Epithelial Cell Biology in Organ Transplantation.- 34. T Cell-Epithelial Cell Interactions in Organ Allograft Rejection.