Quality in Laboratory Hemostasis and Thrombosis (eBook)

Dr Steve Kitchen, Clinical Scientist, Sheffield Hemophila and Thromobosis Centre, Royal Hallamshire Hospital and Scientific Director, UK National External Quality Assessment Scheme (FQAS) for Blood Coagulation, Scientific Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK. John D Olson, Professor and Vice Chair for Clinical Affairs, Department of Pathology, University of Texas Health Sciences Centre, San Antonio, Texas, USA. F. Eric Preston, Emeritus Professsor of Hematology, University of Sheffield and Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulations, Sheffield, UK.

Contributors, vii

Foreword, x

Preface, xii

Steve Kitchen, John D. Olson, & F. Eric Preston

Part 1: General Quality Program

1 General quality planning in the hemostasis laboratory, 3

John D. Olson

2 Hemostasis test validation, performance, and reference
intervals: international recommendations and guidelines, 12

Richard A. Marlar

3 Causes of errors in medical laboratories, 22

Giuseppe Lippi & Emmanuel J. Favaloro

4 International standards in hemostasis, 32

Trevor W. Barrowcliffe & Anthony R. Hubbard

5 Sample integrity and preanalytical variables, 45

Dorothy (Adcock) Funk

6 Internal quality control in the hemostasis laboratory,
57

Steve Kitchen, F. Eric Preston, & John D. Olson

7 External quality assessment in hemostasis: its importance and
significance, 65

F. Eric Preston, Steve Kitchen, & Alok Srivastava

8 The unique challenges of hemostatic testing in children,
77

M. Patricia Massicotte, Mary E. Bauman, Vanessa Chan, &
Anthony K.C. Chan

Part 2: Quality in Coagulation Testing

9 Initial evaluation of hemostasis: reagent and method
selection, 95

Wayne L. Chandler

10 Assay of factor VIII and other clotting factors, 105

Steve Kitchen & F. Eric Preston

11 Application of molecular genetics to the investigation of
inherited bleeding disorders, 115

Stefan Lethagen, Morten Dunø, & Lars Bo Nielsen

12 Detecting and quantifying acquired functional inhibitors in
hemostasis, 124

Bert Verbruggen, Myriam Dardikh, & Britta Laros-van
Gorkom

13 Standardization of d-dimer testing, 136

Guido Reber & Philippe de Moerloose

14 Point-of-care testing in hemostasis, 147

Chris Gardiner, Dianne Kitchen, Samuel Machin, & Ian
Mackie

Part 3: Quality in Testing for Platelet Function and von
Willebrand Disease

15 Diagnostic assessment of platelet function, 159

Paquita Nurden, Alan Nurden, & Martine
Jandrot-Perrus

16 Laboratory evaluation of heparin-induced thrombocytopenia,
174

Theodore (Ted) E. Warkentin & Jane C. Moore

17 Laboratory evaluation of von Willebrand disease: phenotypic
analysis, 192

Emmanuel J. Favaloro

18 Laboratory analysis of von Willebrand disease: molecular
analysis, 204

Anne C. Goodeve & Ian R. Peake

Part 4: Quality in Thrombophilia Testing and Monitoring
Anticoagulation

19 Quality issues in heritable thrombophilia testing, 219

Isobel D. Walker & Ian Jennings

20 Evaluation of antiphospholipid antibodies, 233

Michael Greaves

21 Monitoring heparin therapy, 244

Marilyn Johnston

22 Monitoring oral anticoagulant therapy with vitamin K
antagonists, 253

Armando Tripodi

23 Monitoring new anticoagulants, 264

Elaine Gray & Trevor W. Barrowcliffe

Index, 273