Inflammation and Allergy Drug Design (eBook)

Edited by K. Izuhara, MD, PhD, Saga Medical School, Nabeshima, Japan Stephen T. Holgate, MD, DSc, FRCP, Southampton General Hospital, UK Marsha Wills-Karp, PhD, Children's Hospital Medical Center, Cincinnati, USA

Contributors, vii

Preface, xiii

Part I: Cells contributing to the pathogenesis of allergic
diseases in the respiratory tract

1 Novel anti-infl ammatory drugs based on targeting lung
dendritic cells and airway epithelial cells, 3

Bart N. Lambrecht, Maud Plantinga, Monique Willart, and Hamida
Hammad

2 Role of Th2 cells in the allergic diathesis, 15

Marsha Wills-Karp

3 Importance of Th17- and Th1-associated responses for the
development of asthma, 27

Tomohiro Yoshimoto, Hiroko Tsutsui, and Kenji Nakanishi

4 Regulatory T cells, 39

Chris Corrigan and Kimuli Ryanna

5 A role for natural killer T-cell subsets in the pathogenesis
of various allergic disorders, 59

Hiroshi Watarai, Michishige Harada, Mayumi Tamari, and Masaru
Taniguchi

6 Regulatory roles of B cells in allergy and infl ammation,
67

Kiyoshi Takatsu, Masashi Ikutani and Yoshinori Nagai

7 Mast cells, 79

Mindy Tsai and Stephen J. Galli

8 Eosinophils, 107

Nancy A. Lee, Mark V. Dahl, Elizabeth A. Jacobsen, and Sergei I.
Ochkur

9 Basophils in infl ammation and allergy drug design, 123

Donald MacGlashan, Jr.

10 Epithelial cells, 139

Tillie-Louise Hackett, Stephanie Warner, Dorota Stefanowicz, and
Darryl Knight

11 Fibroblasts, 149

Alastair G. Stewart, Lilian Soon, and Michael Schuliga

12 Airway smooth muscle cells, 163

Andrew J. Halayko and Pawan Sharma

Part II: Cytokines contributing to the pathogenesis of
allergic diseases in the respiratory tract

13 Interleukin 4, interleukin 13, and interleukin 9, 175

Kenji Izuhara, Shoichiro Ohta, Hiroshi Shiraishi, and Shoichi
Suzuki

14 Interleukin 3, interleukin 5, and
granulocyte-macrophage colony-stimulating factor, 187

Alba Llop-Guevara, Josip Marcinko, Ramzi Fattouh, and Manel
Jordana

15 Interleukin 15, interleukin 17, and interleukin 25, 197

Hiroshi Nakajima and Itsuo Iwamoto

16 Thymic stromal lymphopoietin, 205

Kazuhiko Arima and Yong-Jun Liu

17 Interleukin 10, 215

Whitney W. Stevens, Larry Borish, and John W. Steinke

18 Tumor necrosis factor alpha, 225

Christopher Brightling, Latifa Chachi, Dhan Desai, and Yassine
Amrani

19 Profi brotic and angiogenic factors in asthma, 237

Neville Berkman and Francesca Levi-Schaffer

20 Chemokines, 253

Luis M. Teran and Juan R. Velazquez

21 Epithelial growth factors, 263

Yasuhiro Gon and Shu Hashimoto

Part III: Other mediators contributing to the pathogenesis of
allergic diseases in the respiratory tract

22 Prostanoids, 273

Sarah A. Maher, Deborah L. Clarke, and Maria G. Belvisi

23 Leukotrienes, 285

Katsuhide Okunishi and Marc Peters-Golden

24 Proteases in allergy, 297

Keisuke Oboki and Hirohisa Saito

25 Toll-like receptors, 307

Jessica L. Allen, Aurelien Trompette, and Christopher L.
Karp

Index, 317