Severe Acute Respiratory Syndrome (eBook)

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2008 | 1. Auflage
280 Seiten
Wiley (Verlag)
978-0-470-75521-1 (ISBN)

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Prompting the first WHO global health alert for over a decade, Severe Acute Respiratory Syndrome (SARS) was first recognised in South-East Asia in February 2003.

With the causative agent now identified as a new strain of coronavirus, the medical world has gained important knowledge on the aetiology, clinical presentation, diagnosis, pathogenesis, epidemiology, disease treatment and infection control with amazing speed.

Despite this, major gaps remain in our understanding - the race is on to develop new cures and effective vaccines, and the long-term impact on health, society and economics are starting to unravel.

Severe Acute Respiratory Syndrome: A Clinical Guide meets the urgent need for a comprehensive, authoritative reference guide for everyone in the medical and scientific community engaged in the fight against SARS:


  • Definitive book on SARS, clearly and accurately documenting the extraordinary medical and scientific events around this new epidemic
  • International experts in the field, with many contributors from the WHO and CDC
  • Will help reader to understand and prevent future outbreaks with a repeat of the same consequences


Malik Peiris, Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Hong Kong

Larry J Anderson, Chief, Respiratory and Enteric Viruses Branch, MS A34, Centers for Disease Control and Prevention, Atlanta, USA

Albert DME Osterhaus, Department of Virology, Erasmus Medical Centre, The Netherlands

Klaus Stohr, Global Influenza Programme, CDS/CSR, RMD, Switzerland

Kwok-yung Yuen, Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Hong Kong


Prompting the first WHO global health alert for over a decade, Severe Acute Respiratory Syndrome (SARS) was first recognised in South-East Asia in February 2003. With the causative agent now identified as a new strain of coronavirus, the medical world has gained important knowledge on the aetiology, clinical presentation, diagnosis, pathogenesis, epidemiology, disease treatment and infection control with amazing speed. Despite this, major gaps remain in our understanding - the race is on to develop new cures and effective vaccines, and the long-term impact on health, society and economics are starting to unravel. Severe Acute Respiratory Syndrome: A Clinical Guide meets the urgent need for a comprehensive, authoritative reference guide for everyone in the medical and scientific community engaged in the fight against SARS: Definitive book on SARS, clearly and accurately documenting the extraordinary medical and scientific events around this new epidemic International experts in the field, with many contributors from the WHO and CDC Will help reader to understand and prevent future outbreaks with a repeat of the same consequences

Malik Peiris, Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Hong Kong Larry J Anderson, Chief, Respiratory and Enteric Viruses Branch, MS A34, Centers for Disease Control and Prevention, Atlanta, USA Albert DME Osterhaus, Department of Virology, Erasmus Medical Centre, The Netherlands Klaus Stohr, Global Influenza Programme, CDS/CSR, RMD, Switzerland Kwok-yung Yuen, Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Hong Kong

Severe Acute Respiratory Syndrome 5
Contents 7
Contributors 9
Foreword 13
Acknowledgements 17
1. SARS: A Historical Perspective from Hong Kong 19
2. SARS: A Global Perspective 31
3. Clinical Presentation of the Disease in Adults 39
4. SARS in Children 48
5. SARS: Sequelae and Implications for Rehabilitation 54
6. Radiology of SARS 60
7. Aetiology of SARS 68
8. Structure of the Genome of SARS CoV 76
9. Viral Diagnosis of SARS 82
10. Pathology and Pathogenesis 90
11. SARS Coronavirus: An Animal Reservoir? 97
12. Comparative Biology of Animal Coronaviruses: Lessons for SARS 106
13. Epidemiology and Transmission of SARS 122
14. Transmission Dynamics and Control of the Viral Aetiological Agent of SARS 133
15. The Seasonality of Respiratory Virus Diseases: Implications for SARS? 153
16. Public Health Response: A View from Singapore 161
17. Public Health Response: A View from Hong Kong 187
18. Public Health Response: A View from a Region with a Low Incidence of SARS 191
19. Infection Control for SARS: Causes of Success and Failure 198
20. Antiviral Agents for SARS 206
21. Vaccines 225
22. Counting the Economic Cost of SARS 235
23. Preparing for a Possible Resurgence of SARS 253
24. Lessons for the Future: Pandemic Influenza 261
25. Lessons Learnt 271
Appendix 277
Index 279
Colour plate facing page 80 99

"In order to be prepared, those involved in providing
microbiological (and virological) diagnostic services, infectious
disease clinicians and all

those involved in infection control should ensure that they have
ready access to this book. The editors must be congratulated on
ensuring that all 25 chapters were produced and edited only three
years after the first cases were reported - no mean
achievement."

Journal of Hospital Infection

"The book is a 'must-read' for all infection control
nurses involved in planning for pandemic influenza...It is
certainly a text I would like to see as an available resource in
the local healthcare library."

British Journal of Infection Control

Erscheint lt. Verlag 15.4.2008
Sprache englisch
Themenwelt Medizin / Pharmazie Allgemeines / Lexika
Medizinische Fachgebiete Innere Medizin Pneumologie
Schlagworte clinical microbiology • infectious disease • Infektionskrankheiten • Klinische Mikrobiologie • Medical Science • Medizin
ISBN-10 0-470-75521-0 / 0470755210
ISBN-13 978-0-470-75521-1 / 9780470755211
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