Cough (eBook)

Fan Chung is Professor of Respiratory Medicine and Head of Experimental Studies Medicine at National Heart & Lung Institute, Imperial College London, and is Consultant Physician at the Royal Brompton & Harefield NHS Trust, London.

Cough: Causes, Mechanisms and Therapy 4
Contents 7
Contributors 9
Preface 13
Section 1: Introduction 15
1 The clinical and pathophysiological challenge of cough 17
2 Epidemiology of cough 25
3 A brief overview of the mechanisms of cough 31
Section 2: Cough in the Clinic 39
4 Clinical assessment of cough 41
5 Measurement and assessment of cough 53
6 Cough sensitivity: the use of provocation tests 63
7 Causes, assessment and measurement of cough in children 71
8 The quality of life in coughers 89
Section 3: Clinical Conditions with Cough 95
9 Cough in lower airway infections 97
10 Cough and gastro-oesophageal reflux 111
11 Cough in postnasal drip, rhinitis and rhinosinusitis 121
12 Cough and airway hyperresponsiveness 129
13 Cough in chronic obstructive pulmonary disease 139
14 Cough in suppurative airway diseases 151
15 Cough in cancer patients 161
Section 4: Pathophysiology 173
16 Sensory pathways for the cough reflex 175
17 Neurogenesis of cough 187
18 Plasticity of vagal afferent fibres mediating cough 195
19 Motor mechanisms and the mechanics of cough 207
20 Mucus hypersecretion and mucus clearance in cough 221
21 Animal models of cough 231
Section 5: Therapy 237
22 Mechanisms of actions of centrally acting antitussives—electrophysiological and neurochemical analysis 239
23 Pharmacology of peripherally acting antitussives 251
24 Current and potential future antitussive therapies 261
25 Placebo effects of antitussive treatments on cough associated with acute upper respiratory tract infection 273
26 Mucoactive agents for the treatment of cough 283
27 Management of cough 297
Index 313