Environmental Chemicals, Enzyme Function and Human Disease (eBook)

David Evered and Geralyn Lawrenson are the editors of Environmental Chemicals, Enzyme Function and Human Disease and other titles.

Environmental Chemicals Enzyme Function and Human Disease 5
Contents 7
Chairman’s introduction 13
The role of the drug-metabolizing enzymes 17
Discussion 30
The influence of inducers on drug-metabolizing enzyme activity and on formation of reactive drug metabolites in the liver 37
Discussion 51
Effects of inducers and inhibitors on drug-metabolizing enzymes and on drug toxicity in extrahepatic tissues 55
Discussion 72
Induction of enzymes involved in DNA repair and mutagenesis 79
Discussion 91
Induction of drug-metabolizing enzymes by polycyclic aromatic hydrocarbons: mechanisms, and some implications in environmental health research 95
Discussion 106
Induction of drug-metabolizing enzymes by phenobarbitone: structural and biochemical aspects 113
Discussion 106
Substrate-dependent irreversible inactivation of cytochrome P-450: conversion of its haem moiety into modified porphyrins 131
Discussion 143
General Discussion I 153
Regulation of human drug metabolism by dietary factors 159
Discussion 174
Influence of foreign compounds on formation and disposition of reactive metabolites 181
Discussion 195
Pharmacokinetic factors governing the steady-state concentrations of foreign chemicals and their metabolites 203
Discussion 220
Toxicological implications of polymorphic drug metabolism 231
Discussion 283
Immunologically mediated toxicity 257
Discussion 268
Toxicological significance of liver hypertrophy produced by inducers of drug-metabolizing enzymes 273
Discussion 283
The influence of nutrition and inducers on mechanisms of toxicity in humans and animals 301
Discussion 296
Influence of environmental chemicals on drug therapy in humans: studies with contraceptivesteroids 301
Discussion 314
General Discussion II 319
Vitamin D metabolism in patients treated with phenytoin and phenobarbitone 327
Discussion 337
Chemical disease in humans: problems in comparative toxicology 343
Discussion 357
Implications for future studies in humans 361
Final General Discussion 371
Index of Contributors 379
Subject Index 381