Alzheimer's Disease and Related Conditions (eBook)

Sir Gordon Ethelbert Ward Wolstenholme OBE FRCP was a British medical doctor, and the founding director of the Ciba Foundation. He was born in Sheffield, the son of a mechanical engineer, and educated at Repton School and Corpus Christi, Cambridge.

ALZHEIMER'S DISEASE AND RELATED CONDITIONS 5
Contents 7
Chairman's opening remarks 15
Alois Alzheimer and his disease 19
The concept of Alzheimer's disease and its clinical implications 25
Discussion 46
The limbic areas in Alzheimer's disease and in other conditions associated with dementia 51
Discussion 59
Circumscribed cerebral atrophy in Alzheimer's disease: a pathological study 65
Discussion 83
Muscular twitchings in Alzheimer's disease 89
Discussion 103
Cerebral amyloid angiopathy and Alzheimer's disease 109
Atypical Alzheimer's disease with congophilic angiopathy, presenting with dementia of acute onset 119
Discussion 138
The genetics of Alzheimer's disease 151
Discussion 153
The ultrastructure of the neurofibrillary tangle and the senile plaque 159
Discussion 179
The pathology of the synapse in Alzheimer's disease 183
Discussion 194
Neurofibrillary changes in conditions related to Alzheimer's disease 199
Discussion 215
Determination of neurofilament and microtubule density in nerve fibres (what factors control axon calibre?) 223
Discussion 233
An experimental approach to the morphogenesis of neurofibrillary degeneration and the argyrophilic plaque 237
Discussion 255
Biochemistry of neurofilaments and neurotubules 263
Discussion 276
Metabolism of microtubular protein in mouse brain 281
Discussion 290
General discussion 293
Chairman's closing remarks 315
Author index 321
Subject index 323