Drug Responses in Man (eBook)

Sir Gordon Ethelbert Ward Wolstenholme OBE FRCP was a British medical doctor, and the founding director of the Ciba Foundation. He was born in Sheffield, the son of a mechanical engineer, and educated at Repton School and Corpus Christi, Cambridge.

DRUG RESPONSES IN MAN 1
Contents 7
Chairman's opening remarks 13
Pharmacological differences, qualitative and quantitative, between man and other species 15
Discussion 25
Individually different responses to drugs according to age, sex and functional or pathological state 36
Discussion 61
Patterns of metabolic disposition of drugs in man and other species 67
Discussion 75
Patterns of excretion of drugs in man and other species 83
Discussion 94
General Discussion 99
Anaemia, leucopenia and thrombocytopenia due to drug allergy: the importance of cross-reactions 103
Discussion 117
The predictive value of animal tests in relation to drugs affecting the cardiovascular system in man 123
Discussion 130
Predictable and unpredictable responses to drugs: the kidney 137
Discussion 142
The prediction of hepatotoxicity due to therapeutic agents in man 150
Discussion 160
Predictable and unpredictable responses to drugs: the nervous system 168
Discussion 181
General Discussion 187
Drug allergy 194
Discussion 198
Idiosyncrasy and intolerance 201
Discussion 226
Pharmacogenetics and the predictability of drug responses 233
Discussion 246
Final Discussion 252
Chairman’s closing remarks 260
Author Index 264
Subject Index 265