Animal Behaviour and Drug Action (eBook)

Hannah Stienberg and A. V. S. de Reuck are the authors of Animal Behaviour and Drug Action, published by Wiley.

ANIMAL BEHAVIOUR AND DRUG ACTION 5
Contents 11
Middlesex Hospital Medical School Sessions 17
Session 1: Behavioural Analysis of Drug Action 17
The analysis of motivational effects illustrated by experiments on amylobarbitone 17
Discussion 34
Effects of drugs on operant conditioning 39
Discussion 56
The influence of drugs upon memory 60
Discussion 77
The structure of social behaviour and drug action 81
Discussion 96
Discrimination and the frontal lobes of monkeys 100
Session 2: Neurophysiological and Biochemical Correlates of Behavioural Effects of Drugs 108
Amphetamine and neural reward mechanisms 108
Discussion 131
EEG correlates of drug effects 136
Discussion 149
The effect of physostigmine and atropine on the mechanism of learning 152
Discussion 160
The acetylcholine system 162
Discussion 177
Effects of some poisonous substances on the central nervous system 181
Differential effect of rympathomimetic amines on the central nervous system 193
Discussion 206
Session 3: Factors which Modify Effects of Drugs on Behaviour 209
Schedules of reinforcement 209
Discussion 220
Modification of behavioural effects of drugs by past experience 225
Discussion 237
The hereditary base for the action of drugs on animal behaviour 242
Discussion 254
The effects of group composition on drug action 256
Discussion 265
Modification of the effects of drugs on behaviour by the nutritional state 267
Discussion 274
General Discussion 276
Session 4: Relevance of Behavioural Effects o f Drugs in Animals to Effects in Man 282
Screening tests and prediction from animals to man 282
Prediction of drug effects from animals to man 287
Discussion 298
Prediction of clinical effects of psychotropic drugs from animal data 304
Discussion 317
Prediction of clinical response from animal data: a need for theoretical models 319
Discussion 322
Prediction from man to animals 328
Ciba Foundation Sessions on Intermediation between Administered Drugs and Behavioural Effects 334
Session 1: The Biochemical Approach 334
Introduction 334
Discussions 342
Cause-and-effect relationships 342
Variability in response of nervous tissue to stimulation 344
Spreading depression. 347
Ribonucleic acid and behaviour 355
Session 2: The Electrophysiological Approach 358
Introduction 358
Discussions 364
Dissociation of EEG and behaviour 364
Dose levels in animals and man 373
Effect of drugs on eating and drinking 375
Session 3: The Neurophysiological Approach 380
Introduction 380
Discussions 392
Depressant effects of intraventricular adrenaline 392
Spreading depression 394
Localization of brain function 400
Session 4: The Pharmacological Approach 407
Introduction 407
Discussions 411
Transmitter substances 411
Screening tests 413
Ciba Foundation Sessions on the Relevance of Behavioural Effects of Drugs in Animals to their Effects in Man 431
Session 5: Extrapolation from Animals to Man 431
Introduction 431
Discussions 440
Selection of behavioural tests 440
Experiments on animals and man with drug mixtures 442
Strain and sex differences 447
Catatonia 450
Extrapolation from normal to abnormal 460
Factors which modify the effects of drugs on behaviour 465
Session 6: Clinical Implications 476
Introduction 476
Discussions 480
Preclinical investigations 480
Introduction and evaluation of new drugs 490
Index of Authors 494
Subject Index 496