Enzymes and Drug Action (eBook)

J. L. Mongar and A. V. S. de Reuck are the editors of Enzymes and Drug Action, published by Wiley.

ENZYMES AND DRUG ACTION 5
CONTENTS 9
Wellcome Building Sessions 15
Session 1: Enzymes as Primary Points of Drug Action 19
Chairman’s introduction 19
Inhibition of acetylcholinesterase 22
Discussion 31
Carbonic anhydrase inhibition and physiological function 34
Discussion 46
Session 2: Active Transport 49
Pinocytosis 49
Discussion 62
Possible mechanisms of active transport 66
Discussion 80
Effects of drugs on active transport 83
Discussion 105
Session 3: Multiple Mechanisms 106
I. Insulin 106
The explanation of the action of insulin on sugar permeability at molecular level 106
Action of insulin on metabolic reactions 118
Discussion 133
II. Digitalis 138
Action of cardiac glycosides on ionic movements 138
Digitalis: action on metabolism and the contractile system 150
Discussion 173
III. Central Nervous System Depressants 178
Action of barbiturates upon respiratory enzymes 178
Appraising enzymic actions of central depressants by examining cerebral tissues 193
Discussion 222
Session 4: Receptors 229
Relation between enzymes and cholinergic receptors 229
Discussion 243
Induction of receptors 245
Discussion 261
Session 5: Altered Drug Metabolism 264
Chairman's introduction 264
Adaptive enzymes in animals 270
Discussion 299
Drug tolerance 301
Discussion 323
The genetics of drug sensitivity with special reference to suxamethonium 326
Discussion 338
Session 6: Drug Metabolism: Subcellular Aspects 342
Drug metabolism—subcellular mechanisms 342
Discussion 365
Cellular injury by drugs 369
Protection against cellular injury by drugs 384
Discussion 409
Panel Discussion 413
Ciba Foundation Sessions on Drug-Enzyme Interaction at the Molecular Level 426
Session 1: Enzymes 426
Introduction: Enzymes 426
Models of active centres: acetylcholine 435
Active transport 443
Mode of action of insulin 448
Limitations of enzymes as models 454
Session 2: Receptors 460
Introduction: Receptors 460
Definition of receptors 464
Identifying active centres 468
Effect of denervation on receptors 476
Events at the cell membrane 478
Rate theory of drug action 481
Interaction at the Subcellular and Cellular Levels 488
Session 3: Subcellular Level 488
Introduction: Membranes 488
Subcellular particles 497
Phosphatidic acid cycle 503
Antihistamines and membrane permeability 506
Drug concentrations in vitro 509
Session 4: Cellular Level 512
Introduction: Cellular aspects 512
Reconstituting in vitro 513
In vitro and in vivo 519
Microsomal enzymes 522
Endoplasmic reticulum 530
Enzymes in young animals 533
Transaminase and GABA 539
Drug interactions 541
General considerations 543