Histamine (eBook)

Sir Gordon Ethelbert Ward Wolstenholme OBE FRCP was a British medical doctor, and the founding director of the Ciba Foundation. He was born in Sheffield, the son of a mechanical engineer, and educated at Repton School and Corpus Christi, Cambridge.

HISTAMINE 7
CONTENTS 13
SYMPOSIUM OF THE PHYSIOLOGICAL AND PHARMACOLOGICAL SOCIETIES AT THE WELLCOME FOUNDATION 21
Part I : Occurrence of histamine in the body 24
Chairman's opening remarks 22
Distribution of histamine in the body 24
Histamine and mast cells 36
Histamine and intracellular particles 42
Free and conjugated histamine 58
Short Communications 67
Histamine and mast cells 67
Action of 48/80 on the mast cell population and histamine content of the wall of the gastro-intestinal tract of the rat 69
The isolation of imidazoleacetic acid riboside 77
Histaminopexic action of blood serum 78
Inhibition of histidine decarboxylase in vivo by derivatives of benzyl-1-isoquinoline 83
Part II: Release of histamine 85
The mechanism of histamine release 85
Measurement of histamine-releasing activity 100
Histamine release by long chain molecules 118
Histamine release by naturally occurring substances 152
Histamine release and anaphylaxis 167
Short Communications 178
Antihistamine drugs and histamae release, especially in anaphylaxis 178
Release of histamine-clinical considerations 183
The release of cellular histamine in rabbit blood by dextran and dextran sulphate 188
Histamine release and the angio-oedema type of reaction 195
The mode of histamine binding in animal tissues 198
Endogenous histamine liberation in man 201
A slow reacting substance in anaphylaxis-"SRS-A" 203
Some discrepancies in the histamine theory of anaphylaxis in smooth muscle 208
Part III: The origin and significance of histamine in the body 211
The origin and fate of histamine in the body 211
Histamine and gastric secretion 217
Histamine and vasodilatation 248
Histamine and nerves 263
Skin histamine 270
The significance of histaminase in the body 276
Short Communications 286
On the classification and nomenclature of amine oxidases 286
Histamine in nerves 292
Histamine and gastric secretion 298
The effect of sex hormones on histaminase 300
The action of histamine on the sympathetic nervous system 306
Histamine and vasodilator axon reflex of the skin 308
Imidazoleacetic acid metabolism in bacteria 310
SYMPOSIUM AT THE CIBA FOUNDATION 312
Part I : The origin andfate of histamine in the body 313
The origin of histamine in the body 313
Discussion 320
The origin of histamine in the body 326
Discussion 329
The fate of histamine in the body 346
Discussion 357
The fate of histamine in the body with particular reference to the enzymology of histamine oxidation 367
Discussion 377
Is histaminase identical with diamine oxidase? 384
Discussion 401
Part II : Location of histamine in the body, and mechanism of histamine release 409
Remarks on the location of histamine in mammalian tissues 409
Discussion 418
The location of histamine in the body 426
Discussion 431
The mechanism of histamine release 444
Mechanism of histamine release 459
Discussion 471
General Discussion 478