Thalassaemia Syndromes (eBook)

Sir David John Weatherall, GBE, FRS is a British physician and researcher in molecular genetics, haematology, pathology and clinical medicine. J. B. Clegg is the author of The Thalassaemia Syndromes, 4th Edition, published by Wiley.

The Thalassaemia Syndromes 5
Contents 7
Authors and contributors 9
Preface to the fourth edition 11
Preface to the first edition 13
Acknowledgements 15
Part 1 Historical background 17
1 Historical perspectives: the many and diverse routes to our current understanding of the thalassaemias 19
Part 2 The biology of the thalassaemias 79
2 Human haemoglobin 81
3 Thalassaemia: classification, genetics and relationship to other inherited disorders of haemoglobin 137
4 The molecular pathology of the thalassaemias 149
5 The pathophysiology of the thalassaemias 208
6 Distribution and population genetics of the thalassaemias 253
Part 3 Clinical features of the thalassaemias 301
7 The ? thalassaemias 303
8 The ?? and related thalassaemias 373
9 The ? and ?? thalassaemias in association with structural haemoglobin variants 409
10 Hereditary persistence of fetal haemoglobin 466
11 The ? thalassaemias and their interactions with structural haemoglobin variants 500
12 ? Thalassaemia with mental retardation or myelodysplasia 542
13 Thalassaemia intermedia 566
Part 4 Diagnosis and management of thalassaemia 611
14 Avoidance and population control 613
15 Management and prognosis 646
16 The laboratory diagnosis of the thalassaemias 702
Part 5 741
The future 743
References 749
Appendix: Addresses of patient support organizations 839
Index 843

"The book should be part of the library of every haematologist..."

JAMA on the Third Edition

"No library of any consequence should be without this up-to-date
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South African Medical Journal on the Third
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"...the only standard, comprehensive text...a must...They have done
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Clinical and Laboratory Haematology on the Third
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