Lung Cancer (eBook)

Jack A. Roth, MD FACS, Professor and Chairman, Bud JohnsonClinical Distinguished Chair, The University of Texas M.D. AndersonCancer Center, Department of Thoracic & Cardiovascular Surgeryand Professor of Molecular and Cellular Oncology, Director, W.M.Keck Center for Cancer Gene Therapy, Houston, Texas, USA. James D. Cox, MD, Professor and Head, Division ofRadiation Oncology, The University of Texas M.D. Anderson CancerCenter, Houston, Texas, USA. Waun Ki Hong, MD, American Cancer Society ClinicalResearch Professor, Charles A. LeMistre Distinguished Chair inThoracic Oncology and Professor and Chairman, Department ofThoracic/Head and Neck Medical Oncology, The University of TexasM.D. Anderson Cancer Center, Houston, Texas, USA.

Lung Cancer 5
Contents 7
Contributors 9
Preface 13
1 Smoking Cessation 15
2 Lung Cancer Susceptibility Genes 34
3 Lung Cancer Susceptibility and Risk Assessment Models 47
4 The Molecular Genetics of Lung Cancer 75
5 Molecular Biology of Preneoplastic Lesions of the Lung 98
6 Detection of Preneoplastic Lesions 113
7 Treatment of Preneoplastic Lesions of the Lung 125
8 The Pathology and Pathogenesis of Peripheral Lung Adenocarcinoma Including Bronchioloalveolar Carcinoma 135
9 Treatment of Bronchioloalveolar Carcinoma 158
10 Molecular Profiling for Early Detection and Prediction of Response in Lung Cancer 167
11 The Role for Mediastinoscopy in the Staging of Nonsmall Cell Lung Cancer 183
12 Minimally Invasive Surgery for Lung Cancer 194
13 Extended Resections for Lung Cancer 208
14 Adjuvant Chemotherapy Following Surgery for Lung Cancer 235
15 Induction Chemotherapy for Resectable Lung Cancer 247
16 Image-Guided Radiation Therapy 261
17 Stereotactic Body Radiation Therapy for Lung Cancer 270
18 Proton Therapy 285
19 Combinations of Radiation Therapy and Chemotherapy for Nonsmall Cell Lung Carcinoma 297
20 New Chemotherapeutic Agents in Lung Cancer 329
21 Immunologic Approaches to Lung Cancer Therapy 348
22 Epidermal Growth Factor Receptor Inhibitors 366
23 Tumor Angiogenesis: Biology and Therapeutic Implications for Lung Cancer 383
24 Retinoids and Rexinoids in Lung Cancer Prevention and Treatment 400
25 Proteasome Inhibition in Nonsmall Cell Lung Cancer Therapy 414
26 Targeted Genetic Therapy for Lung Cancer 425
27 Screening for Early Detection 435
28 Natural Agents for Chemoprevention of Lung Cancer 455
Index 471
Color plates are found facing, 483

"The current edition builds on the strength of the previouseditions ... .Overall, the book was well planned. Each chapteris a concise review of the recent literature, with detailedreferences. Where warranted, there are tables, black-and-whitediagrams, and photographs that expand on the information providedin the text. This well-organized book will be useful topulmonologists, thoracic surgeons, radiation oncologists, medicaloncologists, and others with an interest in lung cancer."(New England Journal of Medicine, December 2008)

"One of the most comprehensive and up-to-date treatisesthat I have surveyed ... .I would recommend the book highly toanyone in allied disciplines." (Doody's Book Reviews)