Resident Stem Cells and Regenerative Therapy (eBook)

Antonio Carlos Campos de Carvalho, Regina Coeli dos Santos Goldenberg (Herausgeber)

eBook Download: PDF | EPUB

2012 | 1. Auflage
304 Seiten
Elsevier Science (Verlag)
978-0-12-391441-5 (ISBN)

In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures. This book will present the main findings to date and the important factors to be considered when considering resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin, and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. - Highlights basic research in tissue specific stem cells, experiments with animal models and clinical trials that are transforming the field of regeneration - Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research - Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications

In the last 3 decades, stem cells have greatly impacted the scientific and lay communities, providing huge advances in the treatment of devastating human diseases, including myocardial infarction, diabetes, muscular dystrophy, cystic fibrosis, cirrhosis, and osteoporosis. Alongside debates of induced pluripotent stem cells and embryonic stem cells has been the discovery of adult stem cells in many different tissues. While these organ resident or progenitor stem cells offer prospects to contribute to tissue regeneration, they also present challenges because of the complexity of organ structures. This book will present the main findings to date and the important factors to be considered when considering resident stem cells in regenerative therapies. Chapters on cardiac, brain, neural, liver, kidney, skeletal muscle, bone, pancreatic, skin, and lung resident stem cells will assist in defining the level of success that has been achieved and the direction for the road ahead. With contributions from leading laboratories, open questions related to resident stem cells and regenerative therapies will also be presented for debate. - Highlights basic research in tissue specific stem cells, experiments with animal models and clinical trials that are transforming the field of regeneration- Provides a clear understanding of endogenous stem cells, their role in current regenerative therapies, and prospects for future research- Reports on the main-stream clinical approaches and in vivo experiments published in primary literature to help categorizes the advances in various aspects of regenerative therapy and illustrate opportunities for clinical applications

List of Contributors

Mariana Alves Antunes Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Investigação Pulmonar; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Alex Balduino Coordenação de Pesquisa, Universidade Veiga de Almeida (UVA), Rio de Janeiro, Brazil

Radovan Borojevic Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro and Excellion Serviços Biomédicos SA, Petrópolis, Rio de Janeiro

Giordano Wosgrau Calloni Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário-Trindade, 88040-900, Florianópolis, Santa Catarina, Brazil

Arnold I. Caplan Skeletal Research Center, Department of Biology, Case Western Reserve University, Cleveland, Ohio, USA

Adriana B. Carvalho Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Cardiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Antonio Carlos Campos de Carvalho Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Cardiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Instituto Nacional de Cardiologia, Rede de Terapia Celular, Brazil

Karen L. Christman Department of Bioengineering, University of California, San Diego, La Jolla, California, USA

Grazielle Suhett Dias Instituto de Biofísica Carlos Chagas Filho; Laboratório de Cardiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Milene R. Costa Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Físico-Química Biológica Aída Hassón-Voloch; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Maria Eugenia Leite Duarte Centro de Pesquisa em Terapia Celular e Bioengenharia Ortopédica (CTCel), Instituto Nacional de Traumatologia e Ortopedia (INTO), Rio de Janeiro, Brazil Instituto de Ciências Biomédicas (ICB), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil

Marcelo Einicker-Lamas Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Físico-Química Biológica Aída Hassón-Voloch; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Lanuza Alaby Pinheiro Faccioli Instituto de Biofísica Carlos Chagas Filho; Laboratório de Cardiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Bernd K. Fleischmann Institute of Physiology I, Life and Brain Center, University of Bonn, Bonn, Germany

Regina Coeli dos Santos Goldenberg Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Cardiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal doRio de Janeiro, Rio de Janeiro, RJ, Brazil

Fernanda Gubert Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Neurobiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Patrícia M. Kossugue Chemistry Institute, Biochemistry Department, Cell and Molecular Therapy Center (NUCEL), University of São Paulo, São Paulo, Brazil

Rafael S. Lindoso Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Físico-Química Biológica Aída Hassón-Voloch; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Fernando H. Lojudice Chemistry Institute, Biochemistry Department, Cell and Molecular Therapy Center (NUCEL), University of São Paulo, São Paulo, Brazil

Rosalia Mendez-Otero Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Neurobiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Lindolfo da Silva Meirelles University of São Paulo, Ribeirão Preto, São Paulo, Brazil

Louise Mesentier-Louro Instituto de Biofísica Carlos Chagas Filho; Laboratório de Neurobiologia Celular e Molecular; Programa de Terapia Celular e Bioengenharia; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Luiz Fernando Quintanilha de Mesquita Instituto de Biofísica Carlos Chagas Filho; Laboratório de Cardiologia Celular e Molecular; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil; Division of Laboratory, Yamaguchi University Hospital, Yamaguchi University School of Medicine, Japan; Department of Gastroenterology and Hepatology, Yamaguchi University, Graduate School of Medicine Yamaguchi University, Japan

Marcelo Marcos Morales Instituto de Biofísica Carlos Chagas Filho; Laboratório de Fisiologia Celular e Molecular; Programa de Terapia Celular e Bioengenharia; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

Nance Beyer Nardi Laboratory of Stem Cells and Cell Therapy, Universidade Luterana do Brazil, Canoas, Rio Grande do Sul, Brazil

M.I. Nicolescu Molecular Medicine Department, Victor Babeş, National Institute of Pathology, Bucharest, Romania and Division of Cellular and Molecular Medicine, Carol Davila, University of Medicine and Pharmacy, Bucharest, Romania

Bruno Diaz Paredes Instituto de Biofísica Carlos Chagas Filho; Laboratório de Cardiologia Celular e Molecular; Programa de Terapia Celular e Bioengenharia; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Paolo Pelosi Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy

Fernando Pitossi Leloir Institute Foundation, Institute for Biochemical Investigations, CONICET, 1405 Buenos Aires, Argentina

L.M. Popescu Division of Advanced Studies, Victor Babeş, National Institute of Pathology, Bucharest, Romania

Patricia Rieken Macêdo Rocco Instituto de Biofísica Carlos Chagas Filho; Programa de Terapia Celular e Bioengenharia; Laboratório de Investigação Pulmonar; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Isao Sakaida Division of Laboratory, Yamaguchi University Hospital, Yamaguchi University School of Medicine, Japan; Department of Gastroenterology and Hepatology, Yamaguchi University, Graduate School of Medicine Yamaguchi University, Japan

Marcelo F. Santiago Instituto de Biofísica Carlos Chagas Filho; Laboratório de Neurobiologia Celular e Molecular; Programa de Terapia Celular e Bioengenharia; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem -INBEB; Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Eliana Scemes The Dominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, New York, New York,...

Erscheint lt. Verlag	31.12.2012
Sprache	englisch
Themenwelt	Medizin / Pharmazie ► Pflege
	Medizin / Pharmazie ► Physiotherapie / Ergotherapie ► Orthopädie
	Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie
	Naturwissenschaften ► Biologie ► Zellbiologie
	Technik ► Medizintechnik
ISBN-10	0-12-391441-8 / 0123914418
ISBN-13	978-0-12-391441-5 / 9780123914415

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