Spotlight on Familial and Hereditary Gastric Cancer

Buch | Hardcover
211 Seiten
2013
Springer (Verlag)
978-94-007-6569-6 (ISBN)

Lese- und Medienproben

Spotlight on Familial and Hereditary Gastric Cancer -
213,99 inkl. MwSt
This book covers management of hereditary diffuse gastric cancer patients, focusing on E-cadherin germline mutations, clinical criteria definition, genetic screening and molecular mechanisms, pathology and microscopic features, surgical treatment and more.
In this book we have taken a comprehensive look at the subject of familial and hereditary gastric tumors. In particular, the aim of this novel editorial work is to propose the correct management of hereditary diffuse gastric cancer patients, focusing in particular on E-cadherin germline mutations, clinical criteria definition, genetic screening and molecular mechanisms, pathology and microscopic features, surgical treatment and clinical approach for asymptomatic mutation carriers. We also describe other inherited predispositions involving gastric carcinoma.

Foreword.- Preface.-I General Issues.- Historical overview of familial gastric cancer.- Frequency of familial gastric cancer.- The family cancer database.- II Genetics and Epigenetics.- CDH1 gene, structure and function.- E-cadherin germline mutation.- Molecular mechanisms of hereditary diffuse gastric cancer initiation and progression.- Germline missense mutants in hereditary diffuse gastric cancer.- Alternative mechanisms to germline CDH1 mutations in hereditary diffuse gastric cancer.- Beyond CDH1 mutation-causes of hereditary gastric cancer.- Non-CDH1-associated familial gastric cancer and epigenetics factors.-III Pathology.- Hereditary diffuse gastric cancer and lobular breast carcinoma.- Pathology of hereditary diffuse gastric cancer.-IV Management.- Clinical criteria for familial gastric cancer definition.- Prophylactic total gastrectomy in CDH1 germline mutation carrier.- Gastric cancer in other inherited syndromes.- Clinical management of familial gastric cancer.- Appendix.- Index.

Erscheint lt. Verlag 18.6.2013
Zusatzinfo XVIII, 211 p.
Verlagsort Dordrecht
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizinische Fachgebiete Innere Medizin Gastroenterologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Studium 2. Studienabschnitt (Klinik) Humangenetik
Schlagworte E-cadherin • Familial and hereditary • Gastric cancer • Genetics • Magenkrebs
ISBN-10 94-007-6569-X / 940076569X
ISBN-13 978-94-007-6569-6 / 9789400765696
Zustand Neuware
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