Chronopharmaceutics (eBook)

Bi-Botti C. Youan, PharmD, PhD, is Associate Professor of Pharmaceutical Sciences at the University of Missouri-Kansas City School of Pharmacy. He is on the editorial board of the Journal of Environmental Pollution; and a member of the Controlled Release Society, the American Chemical Society, and the American Association of Pharmaceutical Scientists (AAPS). Dr. Youan initiated the first AAPS Sunrise School on Chronopharmaceutical Drug Delivery in 2004. He earned his doctorate from the Université Catholique de Louvain, Brussels, Belgium.

PREFACE.

ACKNOWLEDGMENTS.

CONTRIBUTORS.

ABBREVATION LIST.

INTRODUCTION: TIME, DIAGNOSTICS, AND THERAPEUTICS--BEYOND
CIRCADIAN MARKER RHYTHM-GUIDED TREATMENT (Franz Halberg,
Germaine Corne lissen, and Othild Schwartzkopff).

1 OVERVIEW OF CHRONOPHARMACEUTICS (Bi-Botti C.
Youan).

2 CHRONOGENETICS (Franck Delaunay).

3 CHRONOPHARMACOKINETICS (Bernard Bruguerolle).

4 CHEMICAL OSCILLATOR SYSTEMS FOR CHRONOTHERAPY (Steven A.
Giannos).

5 DIFFUCAPS TECHNOLOGY FOR CONTROLLED RELEASE DRUG DELIVERY
(Gopi Venkatesh).

6 CHRONOTOPICt TECHNOLOGY (M. E. Sangalli, A. Maroni, L.
Zema, M. Cerea, and A. Gazzaniga).

7 CHRONOTHERAPY USING EGALET TECHNOLOGY (Daniel Bar-Shalom,
Clive G. Wilson, and Neena Washington).

8 CHRONSETt: AN OROS DELIVERY SYSTEM FOR CHRONOTHERAPY (Liang
C. Dong, Crystal Pollock-Dove, and Patrick S.L. Wong).

9 CONTROLLED RELEASE MICROCHIPS (Karen Daniel, Hong Linh Ho
Duc, Michael Cima, and Robert Langer).

10 IMPLICATIONS AND APPLICATIONS OF CIRCADIAN SUSCEPTIBILITY
RHYTHMS: CHRONOMICS AND ANESTHESIA (Franz Halberg, Germaine
Corne´ lissen, and Othild Schwartzkopff).

11 TREATMENT WITH OPEN EYES: MARKERS-GUIDED CHRONOTHERANOSTICS
(Germaine Corne lissen, and Franz Halberg).

INDEX.

"[This book] has the challenging subtitle "Science and technology
for biological rhythm-guided therapy and prevention of diseases",
which recognizes the fact, ignored by those developing
pharmaceuticals, that one can also seek specific times when certain
chemical structures best achieve their desired effects with least
undesired consequences.... The book is recommended to all who deal
with pharmaceutics, as well as with pharmacology. As noted by
Bi-Botti C. Youan, whose milestones date back to the 7th century
BCE, it should be part and parcel of the education of all health
care providers and recipients. It could stem enormous current waste
by those who have not yet acquainted themselves with phase-zero
trials. Therein, timing takes first rather than last priority, as
is currently the case in industry. By systematically testing new
drugs at different rhythm stages at the outset, one may not only
avoid discarding a useful drug if tested at the wrong time, but one
may also obtain an estimate of what optimal rhythm stages may be,
and assess the extent of difference in response from administering
the drug at the presumably best or worst times."

--Franz Halberg, M.D., Dr. h.c. (mult.), Halberg
Chronobiology Center University of Minnesota