Hypoparathyroidism
Springer Verlag
978-88-470-5375-5 (ISBN)
Hypoparathyroidism has been written by acknowledged experts in the field and provides essential, up-to-date information on the pathology, diagnosis, and treatment of the condition. It opens by addressing in detail the anatomy and physiology of the parathyroids and describing the epidemiology and clinical presentation of hypoparathyroidism. The full range of hypoparathyroid disorders are then discussed, including the various genetic forms, postoperative hypoparathyroidism, and other forms of acquired hypoparathyroidism. Individual chapters focus on refractory disease, the impact of the condition on bone, and the management of acute hypocalcemia. Both conventional treatment for hypoparathyroidism and the novel replacement therapy with PTH peptides are then thoroughly examined. Pseudohypoparathyroidism is also extensively discussed, with information on the various forms, differential diagnosis, and genetic testing. This book will be of interest to all endocrinologists, and also to surgeons and internal medicine physicians.
Preface.- Part I ANATOMY AND PHYSIOLOGY OF THE PARATHYROID GLANDS.- 1 The History: from Fuller Albright to the sequence of Parathyroid Hormone.- 2 Embryology of the parathyroid glands.- 3 PTH and PTH-related peptides.- 4 PTH assays and their clinical significance.- 5 Calcium-control of PTH secretion.- 6 Phosphate control of PTH secretion.- 7 Role of magnesium in Parathyroid Physiology.- 8 The vitamin D/FGF23/PTH axis.- 9 The PTH receptorsome and transduction pathways.- 10 G protein Gsα and GNAS imprinting.- 11 PTH actions on bone and kidney.- 12 PTH and PTHrp: non‐classical target.- 13 In vitro cellular models of parathyroid cells.- II CONDITIONS OF HYPOPARATHYROIDISM.- 14 Epidemiology of hypoparathyropidism.- 15 Clinical Presentation of Hypoparathyroidism.- 16 Isolated, Familial Hypoparathyroidism.- 17 Autoimmune Hypoparathyroidism.- 18 DiGeorge Syndrome (M. Tarsitano).- 19 Hypoparathyroidism, Deafness and renal dysplasia syndrome.- 20 Hypoparathyroidism, dwarfism, Medullary stenosis of long bones and eye abnormalities (Kenny- Caffey) Syndrome and hypoparathyroidism, retardation and dysmorphism (Sanjad-Sakati) Syndrome.- 21 Hypoparathyroidism in mitochondrial disorders.- 22 Postoperative hypoparathyroidism.- 23 Hypoparathyroidism during pregnancy, lactation, and fetal/neonatal development.- 24 Other forms of acquired hypoparathyroidism (radiation‐induced, infiltrative disorders, heavy‐metal storage disorders, post burn, maternal hyperparathyroidism).- 25 Refractory hypoparathyroidism.- 26 Bone features in hypoparathyroidism.- 27 Management of acute hypocalcemia.- 28 Conventional Treatment in chronic hypoparathyroidism.- 29 Follow‐up in chronic hypoparathyroidism.- 30 Replacement therapy with PTH1-34.- 31 Replacement Therapy with PTH1-84.- III FUNCTIONAL HYPOPARATHYROIDISM.- 32 Classification of pseudohypoparathyroidism and differential diagnosis.- 33 Pseudohypoparathyroidism type Ia, Pseudopseudohypoparathyroidism and Albright HereditaryOsteodystrophy.- 34 Pseudohypoparathyroidisms other than Ia.- 35 Genetic testing in pseudo-hypoparathyroidism.- 36 Blomstrand’s chondrodystrophy.- 37 Hypoparathyroidism during magnesium deficiency or excess.- IV ADVOCATING FOR HYPOPARATHYROIDISM.- 38. Advocating For Hypoparathyroidism.
| Zusatzinfo | 37 Illustrations, color; 30 Illustrations, black and white; XVII, 429 p. 67 illus., 37 illus. in color. |
|---|---|
| Verlagsort | Milan |
| Sprache | englisch |
| Maße | 178 x 254 mm |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Chirurgie |
| Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie | |
| Studium ► 1. Studienabschnitt (Vorklinik) ► Physiologie | |
| Schlagworte | Hyperparathyroidism • Hypoparathyroidism • Parathyroid hormone • Parathyroid physiology • parathyroids • Parathyroid Surgery |
| ISBN-10 | 88-470-5375-7 / 8847053757 |
| ISBN-13 | 978-88-470-5375-5 / 9788847053755 |
| Zustand | Neuware |
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