Vanilloid Receptor TRPV1 in Drug Discovery (eBook)

ARTHUR GOMTSYAN is an Associate Research Fellow at Abbott Laboratories where he focuses on neuroscience research and pain drug targets. He is on the editorial board of two peer-reviewed journals and has over forty scientific articles to his credit. CONNIE R. FALTYNEK is a Director for Neuroscience and Pain Discovery at Abbott Laboratories. She has twenty years' experience in drug discovery research in the pharmaceutical industry and has published nearly 100 scientific papers.

Preface and Acknowledgments.

Foreword.

Contributors.

PART I INTRODUCTION TO THE TRP CHANNELS.

1 TRP Channels and Human Diseases (Bernd Nilius and Rudi
Vennekens).

2 Role of TRP Channels in Pain: An Overview (Arpad
Szallasi).

3 Biochemical Pharmacology of TRPV1: Molecular Integrator of
Pain Signals (Carol S. Surowy, Philip R. Kym, and Regina M.
Reilly).

4 TRPV1 Genetics (Ruslan Dorfman, Hubert Tsui, Michael W.
Salter, and H.-Michael Dosch).

PART II ROLE FOR TRPV1 IN PAIN STATES.

5 TRPV1 and Inflammatory Pain (Anindya Bhattacharya, Sonya G.
Lehto, and Narender R. Gavva).

6 Role of TRPV1 Receptors in Osteoarthritic Pain (Shailen K.
Joshi and Prisca Honore).

7 TRPV1 and Bone Cancer Pain (Juan Miguel Jimenez-Andrade and
Patrick Mantyh).

8 TRPV1 in Visceral Pain and Other Visceral Disorders
(António Avelino and Francisco Cruz).

9 TRPV1 Receptors and Migraine (Philip R. Holland and Peter
J. Goadsby).

10 TRPV1 in Neuropathic Pain and Neurological and
Neuropsychiatric Disorders (Enza Palazzo, Katarzyna Starowicz,
Sabatino Maione, and Vincenzo Di Marzo).

PART III TRPV1 ANTAGONISTS AND AGONISTS AS NOVEL ANALGESIC
DRUGS.

11 Aryl-Urea Class and Related TRPV1 Antagonists (Arthur
Gomtsyan).

12 2-Pyridinylpiperazine Carboxamide Class and Related TRPV1
Antagonists (Natalie A. Hawryluk and Nicholas I.
Carruthers).

13 TRPV1 Agonist Approaches for Pain Management (Keith R.
Bley).

PART IV ROLE FOR TRPV1 IN OTHER PHYSIOLOGICAL PROCESSES
BESIDES PAIN TRANSMISSION.

14 The TRPV1 Channel in Normal Thermoregulation: What Have We
Learned from Experiments Using Different Tools? (Andras Garami,
Maria C. Almeida, Tatiane B. Nucci, Tamara Hew-Butler, Renato N.
Soriano, Eszter Pakai, Kazuhiro Nakamura, Shaun F. Morrison, and
Andrej A. Romanovsky).

15 The Role of TRPV1 in Respiratory Diseases (Serena
Materazzi, Alain Tchoimou, Romina Nassini, Marcello Trevisani, and
Pierangelo Geppetti).

16 The Role of TRPV1 in Diabetes (Hubert Tsui, Ruslan
Dorfman, Michael W. Salter, and H.-Michael Dosch).

Afterword.

Index.