Flavonoid Pharmacokinetics (eBook)

Neal M. Davies, PhD. is Dean of Professor in the Faculty of Pharmacy at the University of Manitoba. He has also held faculty positions at the University of Sydney and Washington State University. Dr. Davies's research focuses on pharmaceutics and the pharmacokinetics and pharmacodynamics of natural products. He is a graduate of the University of Alberta. Jaime A. Yáñez, PhD. is Senior Study Director in Drug Metabolism and Pharmacokinetics at Alcon Research, Ltd., a Novartis Company. Previously, he worked at Schering-Plough Research Institute and Merck Research Laboratories. He also serves as Adjunct Faculty and Research Consultant at Universities and research organizations in Peru, Mexico, Spain and the United States. Dr. Yáñez's expertise spans preclinical and clinical pharmacokinetics, pharmacodynamics, pharmaceutics, and predictive computer modeling and simulation, all with an emphasis on natural products.

Foreword ix

Preface xiii

Contributors xv

1 Polyphenols and Flavonoids: An Overview 1
Jaime A. Yáñez, Connie M. Remsberg, Jody K. Takemoto, Karina R. Vega-Villa, Preston K. Andrews, Casey L. Sayre, Stephanie E. Martinez, and Neal M. Davies

2 Analysis of Flavonoids through Chromatography 71
Jody K. Takemoto, Stephanie E. Martinez, and Neal M. Davies

3 Chiral Methods of Flavonoid Analysis 117
Jaime A. Yáñez, Casey L. Sayre, Stephanie E. Martinez, and Neal M. Davies

4 Preclinical Pharmacokinetics of Flavonoids 161
Jaime A. Yáñez, Casey L. Sayre, and Neal M. Davies

5 Clinical Pharmacokinetics of Flavonoids 195
Casey L. Sayre, Karen D. Gerde, Jaime A. Yáñez, and Neal M. Davies

6 Toxicology and Safety of Flavonoids 249
Stephanie E. Martinez, Neal M. Davies, and Jonathan K. Reynolds

7 Flavonoids and Drug Interactions 281
Jaime A. Yáñez, Nagendra V. Chemuturi, Scott W. Womble, Casey L. Sayre, and Neal M. Davies

Index 321