MicroRNAs in Medicine

Dr. Charles Lawrie is Director of Oncology at the Biodonostia Institute in San Sebastián, Spain. The author of numerous research papers and book chapters, Dr. Lawrie is an Associate Editor for the Journal of Cancer Research, and serves on the editorial boards of a number of other prestigious journals including Cancers, Journal of RNAi and Gene Silencing, American Journal of Blood, and ISRN Hematology.

Foreword ix
Sir David Baulcombe Preface xi

Contributors xiii

1 MICRORNAS: A BRIEF INTRODUCTION 1
Charles H. Lawrie

PART I: MICRORNAS AS PHYSIOLOGICAL REGULATORS 25

2 MICRORNA REGULATION OF STEM CELL FATE AND REPROGRAMMING 27
Erika Lorenzo Vivas, Gustavo Tiscornia, and Juan Carlos Izpisua Belmonte

3 MICRORNAS AS REGULATORS OF IMMUNITY 41
Donald T. Gracias and Peter D. Katsikis

4 REGULATION OF SENESCENCE BY MICRORNAS 59
Ioannis Grammatikakis and Myriam Gorospe

5 THE EMERGENCE OF GEROMIRS: A GROUP OF MICRORNAS IMPLICATED IN AGING 77
Alejandro P. Ugalde, Agnieszka Kwarciak, Xurde M. Caravia, Carlos López-Otín, and Andrew J. Ramsay

6 MICRORNAS AND HEMATOPOIESIS 91
Sukhinder K. Sandhu and Ramiro Garzon

7 MICRORNAS IN PLATELET PRODUCTION AND ACTIVATION 101
Leonard C. Edelstein, Srikanth Nagalla, and Paul F. Bray

PART II: MICRORNAS IN INFECTIOUS DISEASE: HOST–PATHOGEN INTERACTIONS 117

8 MICRORNAS AS KEY PLAYERS IN HOST-VIRUS INTERACTIONS 119
Aurélie Fender and Sébastien Pfeffer

9 MICRORNA EXPRESSION IN AVIAN HERPESVIRUSES 137
Yongxiu Yao and Venugopal Nair

10 FUNCTION OF HUMAN CYTOMEGALOVIRUS MICRORNAS AND POTENTIAL ROLES IN LATENCY 153
Natalie L. Reynolds, Jon A. Pavelin, and Finn E. Grey

11 INVOLVEMENT OF SMALL NON-CODING RNA IN HIV-1 INFECTION 165
Guihua Sun, John J. Rossi, and Daniela Castanotto

12 MICRORNA IN MALARIA 183
Panote Prapansilp and Gareth D.H. Turner

PART III: CANCER 199

13 THE MICRORNA DECALOGUE OF CANCER INVOLVEMENT 201
Tanja Kunej, Irena Godnic, Minja Zorc, Simon Horvat, and George A. Calin

14 MICRORNAS AS ONCOGENES AND TUMOR SUPPRESSORS 223
Eva E. Rufi no-Palomares, Fernando J. Reyes-Zurita, Jose Antonio Lupiáñez, and Pedro P. Medina

15 LONG NON-CODING RNAS AND THEIR ROLES IN CANCER 245
Yolanda Sánchez and Maite Huarte

16 REGULATION OF HYPOXIA RESPONSES BY MICRORNA EXPRESSION 267
Carme Camps, Adrian L. Harris, and Jiannis Ragoussis

17 CONTROL OF RECEPTOR FUNCTION BY MICRORNAS IN BREAST CANCER 287
Claudia Piovan and Marilena V. Iorio

18 MICRORNAS IN HUMAN PROSTATE CANCER: FROM PATHOGENESIS TO THERAPEUTIC IMPLICATIONS 311
Mustafa Ozen and Omer Faruk Karatas

19 MICRORNA SIGNATURES AS BIOMARKERS OF COLORECTAL CANCER 329
Katrin Pfütze, Xiaoya Luo, and Barbara Burwinkel

20 GENETIC VARIATIONS IN MICRORNA-ENCODING SEQUENCES AND MICRORNA TARGET SITES ALTER LUNG CANCER SUSCEPTIBILITY AND SURVIVAL 343
Ming Yang and Dongxin Lin

21 MICRORNA IN MYELOPOIESIS AND MYELOID DISORDERS 353
Sara E. Meyer and H. Leighton Grimes

22 MICRORNA DEREGULATION BY ABERRANT DNA METHYLATION IN ACUTE LYMPHOBLASTIC LEUKEMIA 371
Xabier Agirre and Felipe Prósper

23 ROLE OF MIRNAS IN THE PATHOGENESIS OF CHRONIC LYMPHOCYTIC LEUKEMIA 383
Veronica Balatti, Yuri Pekarsky, Lara Rizzotto, and Carlo M. Croce

24 MICRORNA IN B-CELL NON-HODGKIN’S LYMPHOMA: DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS 403
Nerea Martínez, Lorena Di Lisio, and Miguel Angel Piris

25 MICRORNAS IN DIFFUSE LARGE B-CELL LYMPHOMA 419
Izidore S. Lossos and Alvaro J. Alencar

26 THE ROLE OF MICRORNAS IN HODGKIN’S LYMPHOMA 435
Wouter Plattel, Joost Kluiver, Arjan Diepstra, Lydia Visser, and Anke van den Berg

27 MICRORNA EXPRESSION IN CUTANEOUS T-CELL LYMPHOMAS 449
Cornelis P. Tensen

PART IV: HEREDITARY AND OTHER NON-INFECTIOUS DISEASES 463

28 MICRORNAS AND HEREDITARY DISORDERS 465
Matías Morín and Miguel A. Moreno-Pelayo

29 MICRORNAS AND CARDIOVASCULAR DISEASES 477
Koh Ono

30 MICRORNAS AND DIABETES 495
Romano Regazzi

31 MICRORNAS IN LIVER DISEASES 509
Patricia Munoz-Garrido, Marco Marzioni, Elizabeth Hijona, Luis Bujanda, and Jesus M. Banales

32 MICRORNA REGULATION IN MULTIPLE SCLEROSIS 523
Andreas Junker

33 THE ROLE OF MICRORNAS IN ALZHEIMER’S DISEASE 539
Shahar Barbash and Hermona Soreq

34 CURRENT VIEWS ON THE ROLE OF MICRORNAS IN PSYCHOSIS 553
Aoife Kearney, Javier A. Bravo, and Timothy G. Dinan

PART V: CIRCULATING MICRORNAS AS CELLULAR MESSENGERS AND NOVEL BIOMARKERS 567

35 CIRCULATING MICRORNAS AS NON-INVASIVE BIOMARKERS 569
Heidi Schwarzenbach and Klaus Pantel

36 CIRCULATING MICRORNAS AS CELLULAR MESSENGERS 589
Kasey C. Vickers

37 RELEASE OF MICRORNA-CONTAINING VESICLES CAN STIMULATE ANGIOGENESIS AND METASTASIS IN RENAL CARCINOMA 607
Federica Collino, Cristina Grange, and Giovanni Camussi

PART VI: THERAPEUTIC USES OF MICRORNAS: CURRENT PERSPECTIVES AND FUTURE DIRECTIONS 623

38 MICRORNA REGULATION OF CANCER STEM CELLS AND MICRORNAS AS POTENTIAL CANCER STEM CELL THERAPEUTICS 625
Can Liu and Dean G. Tang

39 THERAPEUTIC MODULATION OF MICRORNAS 639
Achim Aigner and Hannelore Dassow

40 LOCKED NUCLEIC ACIDS AS MICRORNA THERAPEUTICS 663
Henrik Ørum

Index 673