Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance - E.E. Müller

Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance

From Basic to Clinical Research

(Autor)

Buch | Softcover
197 Seiten
2012 | Softcover reprint of the original 1st ed. 2003
Springer Verlag
978-88-470-2170-9 (ISBN)
149,79 inkl. MwSt
Describes the ability of a series of endocrine-derived compounds, i.e. CHRH, LHRH, somatostatin, anti-androgens, and aromatase inhibitors to exert a direct anti-neoplastic activity or to potentiate the activity of traditional chemotherapeutic agents on neuroendocrine and solid tumors. In addition, a new class of potent GH-releasers, GSHs/Ghrelin, endowed with important endocrine and extra-endcocrine action, is presented. Therefore, in addition to traditional chemotherapy, characterized by high toxicity and non-selective action on tumoral cells, the reader can find a new approach with more selective, less cytotoxic endocrine derived compounds.

LHRH/Somatostatin.- Chapter1 Twenty-five Years of Endocrine Oncology with Analogs of Hypothalamic Peptides: an Overview.- Chapter2 Analogs of Luteinizing Hormone-releasing Hormone in Benign Prostatic Hyperplasia and Advanced Renal Cell Carcinoma.- Chapter3 Luteinizing Hormone-releasing Hormone Antagonists in Gynecology.- Chapter4 Physiology and Pharmacology of Somatostatin and Its Receptors.- Chapter5 Investigation of LHRH Receptor Involvement in Melanoma Growth and Progression.- Somatostatin/GHRH/GH.- Chapter6 Cortistatin: Not Simply a Natural Somatostatin Analogue.- Chapter7 Antineoplastic and Antiangiogenic Actions of Somatostatin Analogs.- Chapter8 Somatostatin in Clinical Endocrinology.- Chapter9 Antagonists of Growth Hormone-releasing Hormone in Oncology.- Chapter10 GH Receptor Antagonists: Basic Knowledge and Clinical Perspectives.- Ghrelin and Ghrelin Mimetics (GHS).- Chapter11 Hypothalamic Circuits Responsive to Ghrelin: Regulation by Leptin and Insulin.- Chapter12 Physiological Function of Growth Hormone Secretagogue Receptors in the Cardiovascular System.- Chapter13 Endocrine and Extraendocrine Activity of Ghrelin and the GHS: Basic Research.- Chapter14 Endocrine and Nonendocrine Actions of Ghrelin and GHS: State of the Art in Clinical Research.- Hormonal Treatments for Endocrine-Dependent Tumors.- Chapter15 Hormonal Treatments of Endocrine-Dependent Tumors: Preclinical Aspects.- Chapter16 Hormonal Treatment of Endocrine-Dependent Tumors: Clinical Considerations.- Chapter17 Letrozole in the Treatment of Advanced Breast Cancer.

Zusatzinfo XII, 197 p.
Verlagsort Milan
Sprache englisch
Maße 155 x 235 mm
Themenwelt Medizinische Fachgebiete Innere Medizin Endokrinologie
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Pflege
Studium 1. Studienabschnitt (Vorklinik) Biochemie / Molekularbiologie
Schlagworte actions hormonal • Chemotherapy of neuroendocrine • endocrine • endocrine dependent tumors • extra-endocrine • GHRH antagonists • GHSs/Ghrelin • solid tumors • Somatostatin analogs
ISBN-10 88-470-2170-7 / 8847021707
ISBN-13 978-88-470-2170-9 / 9788847021709
Zustand Neuware
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