Cirrhosis – A practical guide to management

Samuel S. Lee, MD, Professor, Department of Medicine and Head,Division of Gastroenterology, University of Calgary, Canada. SamLee is one of the world s leading lights on cirrhosis and iseditor-in-chief of the Wiley journal Liver International,the official journal of the International Association for the Study of theLiver. Richard Moreau, MD, Head and Director of Research at theNational Institute of Health (Inserm), Paris, France.

List of contributors vii Foreword xi List of abbreviations xiii Part 1: Diagnosis and pathophysiology 1 Clinical clues to the diagnosis of cirrhosis 3 Y.K. Chawla and Vijay Bodh 2 Diagnostic laboratory tests 12 Ying-Ying Yang and Han-Chieh Lin 3 Diagnostic imaging modalities 21 Soon Koo Baik Moon Young Kim and Woo Kyoung Jeong 4 Histology/pathology 35 Valerie Paradis 5 Fibrosis and fibrogenesis 46 Namiki Izumi Nobuharu Tamaki Yasuhiro Asahina and Masayuki Kurosaki 6 Non-invasive diagnosis tests 53 Laurent Castera 7 Evaluating prognosis 63 Sumeet K. Asrani and Patrick S. Kamath 8 End-stage liver failure: liver transplant evaluation 75 Sebastian Marciano and Adrian Gadano Part 2: Complications of cirrhosis 9 Acute-on-chronic liver failure 87 Danielle Adebayo Vincenzo Morabito and Rajiv Jalan 10 Hepatocellular carcinoma 94 Kwang-Hyub Han and Do Young Kim 11 Hepatic encephalopathy 105 Piero Amodio 12 Malnutrition and nutritional support 124 Jian-Gao Fan and Hai-Xia Cao 13 Varices portal hypertensive gastropathy and GAVE 137 Isabelle Colle Xavier Verhelst Anja Geerts and Hans Van Vlierberghe 14 Ascites 151 Andres Cardenas Isabel Graupera and Pere Gines 15 Spontaneous bacterial peritonitis and other infections 164 Thierry Gustot and Richard Moreau 16 Hepatorenal syndrome and acute kidney injury 175 Florence Wong 17 The hepatopulmonary syndrome 189 Moises Ilan Nevah Rubin and Michael B. Fallon 18 Hyponatremia and other electrolyte/ion disorders 199 Salvatore Piano Filippo Morando and Paolo Angeli 19 Portopulmonary hypertension 212 Rodrigo Cartin-Ceba and Michael J. Krowka 20 Cirrhotic cardiomyopathy 225 Hongqun Liu and Samuel S. Lee 21 Adrenal insufficiency 236 Emily Dannhorn and James O Beirne 22 Coagulopathy and clotting disorders 249 Marco Senzolo and A.K. Burroughs 23 Agents and drugs: precautions in patients with cirrhosis 261 Felix Stickel 24 Changing outcomes with antiviral or antifibrotic therapies 274 Gamal Esmat and Maissa El Raziky 25 Bone disorders 283 Jane Collier 26 Pruritus 291 Nora V. Bergasa 27 Quality of life and symptom management 301 Ayman A. Abdo and Faisal M. Sanai 28 Special considerations in children 311 Alejandro Costaguta and Fernando Alvarez Index 323