Drug-Induced Liver Disease

Part I. Mechanisms of Liver Injury Chapter 1: Drug-Induced Liver Injury: Introduction and Overview Chapter 2: Cytochrome P450 Activation of Toxins and Hepatotoxicity Chapter 3: Mechanistic Role of Acyl Glucuronides Chapter 4: Oxidative Stress, Antioxidant Defense and Liver Injury Chapter 5: Hepatotoxicity due to Mitochondrial Injury Chapter 6: Mechanisms of Cell Death and Relevance to Drug Hepatotoxicity Chapter 7: Role of Membrane Transport in Hepatotoxicity and Pathogenesis of Drug-Induced Cholestasis Chapter 8: Liver Sinusoidal Endothelial Cell and Liver Injury Chapter 9: Macrophages and Kupffer Cells in Hepatotoxicity Chapter 10: Role of Inflammation in Drug-Induced Liver Disease Chapter 11: Role of Adaptive Immune System Chapter 12: Role of Tissue Repair in Liver Injury Chapter 13: Genetic Factors in Pathogenesis

Part II. Diagnosis and ManagementChapter 14: Clinical Manifestations and Management of Drug-Induced Liver Diseases Chapter 15: Histopathology of Drug-Induced Liver Disease Chapter 16: Risk Factors for Drug-Induced Liver Disease Chapter 17: The Promise of Genomics, Proteomics and Metabolomics of Blood and Liver in the Diagnosis of Drug-Induced Liver Disease Chapter 18: Causality Assessment

Part III. Hepatotoxicity of Specific DrugsChapter 19: Mechanisms of Acetaminophen-Induced Liver Disease Chapter 20: Acetaminophen – Pathology and Clinical Presentation of Hepatotoxicity Chapter 21: Mechanisms Underlying the Hepatotoxicity of Non-Steroidal Anti-Inflammatory Drugs Chapter 22: Non-Steroidal Anti-Inflammatory Drugs – Pathology and Clinical Presentation of Hepatotoxicity Chapter 23: Mechanisms, Pathology and Clinical Presentation of Hepatotoxicity of Anesthetic Agents Chapter 24: Anticonvulsant AgentsChapter 25: Psychotropic Drugs and Drugs of Abuse Chapter 26: Hepatotoxicity of Antimicrobials and Antifungal Agents Chapter 27: Antituberculosis Agents Chapter 28: Hepatotoxicity in Antiviral Agents Chapter 29: Hepatotoxicity of Cardiovascular and Antidiabetic Drugs Chapter 30: Cancer Chemotherapy Chapter 31: Hepatotoxicity of Immunomodulating Agents and the Transplant Situation Chapter 32: Methotrexate Chapter 33: Hormones and Hormone Antagonists Chapter 34: Mushroom Poisoning: A Clinical Model of Toxin-Induced Centrilobular Necrosis Chapter 35: Hepatotoxicity and Herbal Medicines, Vitamins and Natural Hepatoxins Chapter 36: Occupational and Environmental HepatotoxicityChapter 37: Chronic Liver Disease from Drugs

Part IV. Future DirectionsChapter 38: Regulatory Perspectives Chapter 39: Drug-Induced Liver Injury Networks Chapter 40: Liver Tox: The Future