Gene-Environment Interactions (eBook)
576 Seiten
John Wiley & Sons (Verlag)
978-0-471-75803-7 (ISBN)
relating it to disease causation, is the task of ecogenetics.
Gene-Environment Interactions: Fundamentals of Ecogenetics presents
the first comprehensive survey of this discipline, reflecting its
relationship with toxicology, epidemiology, pharmacology, public
health, and other medical and biological fields.
Divided into four sections, the text elucidates key basic and
advanced topics:
* Section 1 covers fundamentals, including the history of the
discipline, a discussion of the molecular laboratory tools
currently available to assess genotypes, using such measurements in
molecular epidemiology studies, and the statistical issues involved
in their analysis.
* Section 2 focuses on a number of key genetic polymorphisms
relevant for ecogenetics, including enzymes of phase I and phase II
metabolism, enzymes involved in DNA repair, as well as receptors
and ion channels. This highlights characteristics of selected,
widely studied genotypic/phenotypic differences, and allows
discussion of how given genetic variations can influence responses
to exogenous chemicals.
* Section 3 examines gene-environment interactions through a
disease-based approach, addressing how genetic polymorphisms can
influence susceptibility to various diseases. Chapters cover
important disease conditions such as various types of cancer,
neurodegenerative diseases, cardiovascular disease, chronic
pulmonary diseases, infectious diseases, diabetes, and
obesity.
* The final section discusses the ethical, legal, and social issues
that arise when investigating and evaluating genetic polymorphisms
in human populations, as well as the impact of ecogenetics on risk
assessment, regulatory policies, and medicine and public
health.
Packed with clear examples illustrating concepts, as well as
numerous tables and figures, Gene-Environment Interactions:
Fundamentals of Ecogenetics is a unique resource for a wide range
of physicians, students, and other specialists.
Lucio G. Costa, Ph.D., is professor of environmental health and toxicology at the University of Washington School of Public Health and Community Medicine. He is also director of the NIEHS-sponsored Neurotoxicology Research Core at the Center in Ecogenetics and Environmental Health. His research is focused on the study of the cellular, biochemical and molecular mechanisms involved in neurotoxicity using biochemical, molecular and imaging techniques. David L. Eaton is Professor of Environmental Health and Associate Dean for Research in the School of Public Health and Community Medicine at the University of Washington. He serves as Director of the Center for Ecogenetics and Environmental Health, and is also Deputy Director for a major NIEHS-sponsored research initiative in the area of toxicogenomics. Dr. Eaton's research interests focus on understanding how subtle genetic differences between individuals and species can result in potentially large differences in susceptibility to chemical carcinogens.
Foreword.
Acknowledgments.
Contributors.
PART I.
Chapter 1. Introduction (Lucio G. Costa and David L. Eaton).
Chapter 2. Ecogenetics: Historical Perspectives (Gilbert S.
Omenn and Arno G. Motulsky).
Chapter 3. Tools of Ecogenetics (Theo K. Bammler, Federico M.
Farin, and Richard P. Beyer).
Chapter 4. Epidemiologic Approaches (Harvey Checkoway, Parveen
Bhatti, and Anneclaire De Roos).
Chapter 5. Statistical Issues in Ecogenetic Studies (Stephanie
A. Monks).
PART II.
Chapter 6. Overview of Section II (Lucio G. Costa and David L.
Eaton).
Chapter 7. Polymorphisms in Cytochrome P450 and
Flavin-Containing Monooxygenase Genes (Catherine K.Yeung, Allan E.
Rettie, and Kenneth E. Thummel)
Chapter 8. Polymorphisms in Xenobiotic Conjugation (Helen E.
Smith, David L. Eaton, and Theo K. Bammler).
Chapter 9. Paraoxonase, Butyrylcholinesterase, and Epoxide
Hydrolase (Lucio G. Costa, Toby B. Cole, Gary K. Geiss, and Clement
E. Furlong).
Chapter 10. DNA Repair Enzymes (Jon P. Anderson and Lawrence A.
Loeb).
Chapter 11. Receptors and Ion Channels (Lucio G. Costa).
PART III.
Chapter 12. Overview of Section III (Lucio G. Costa and David L.
Eaton).
Chapter 13. Lung Cancer (Valle Nazar-Stewart).
Chapter 14. Gastrointestinal Cancers (Thomas L.Vaughan).
Chapter 15. Neurodegenerative Diseases (Samir N. Kelada, Harvey
Checkoway, and Lucio G. Costa).
Chapter 16. Cardiovascular Disease (Melissa A.Austin and Stephen
M. Schwartz).
Chapter 17. Type 2 Diabetes (Karen L. Edwards).
Chapter 18. Infectious Disease Ecogenetics (David R.
Sherman).
Chapter 19. Genetic Variation, Diet, and Disease Susceptibility
(Johanna W. Lampe and John D. Potter).
Chapter 20. Genetic Determinants of Addiction to Alcohol,
Tobacco, and Drugs of Abuse (Andrew J. Saxon).
PART IV.
Chapter 21. Overview of Section IV (Lucio G. Costa and David L.
Eaton).
Chapter 22. Ethical Issues in Ecogenetics (Kelly Fryer-Edwards,
Lindsay A. Hampson, Christopher R. Carlsten, and Wylie Burke).
Chapter 23. Social and Psychological Aspects of Ecogenetics
(Deborah Bowen, Shirley Beresford, and Brenda Diergaarde).
Chapter 24. Legal Issues (Kate Battuello and Anna
Mastroianni).
Chapter 25. Risk Assessment and the Impact of Ecogenetics
(Elaine M. Faustman and Gilbert S. Omenn).
Bibliography.
Index.
"...highly recommended for academic libraries that have
undergraduate and graduate studies in genetics, toxicology, and
pharmacology." (E-STREAMS, September 2007)
"...a great accomplishment, and it can well serve as a primary,
extensively-referenced text..." (American Journal of Medical
Genetics, Part A, August 1, 2007)
"...a must-have for all toxicology and pharmacology students as
well as a great resource for researchers and physicians."
(Environmental Health Perspectives, June 2006)
"...a vital in-office reference for any scientific researcher
dedicated to the study of genetics...invaluable to public health
researchers who are look at how global threats live Avian Flu might
spread to the general populous...an indispensable reference to all
health science libraries." (The Electric Review, March/April
2006)
| Erscheint lt. Verlag | 2.3.2006 |
|---|---|
| Sprache | englisch |
| Themenwelt | Studium ► 2. Studienabschnitt (Klinik) ► Humangenetik |
| Naturwissenschaften ► Biologie ► Genetik / Molekularbiologie | |
| Technik | |
| Schlagworte | Biowissenschaften • Chemie • Chemistry • Genetics • Genetik • Life Sciences • Medical Science • Medizin • Oncology & Radiotherapy • Onkologie • Onkologie u. Strahlentherapie • Toxicology • Toxikologie |
| ISBN-10 | 0-471-75803-5 / 0471758035 |
| ISBN-13 | 978-0-471-75803-7 / 9780471758037 |
| Haben Sie eine Frage zum Produkt? |
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