Model Organisms in Drug Discovery (eBook)

Pamela M. Carroll is the editor of Model Organisms in Drug Discovery, published by Wiley. Kevin Fitzgerald is the editor of Model Organisms in Drug Discovery, published by Wiley.

List of contributors.

Acknowledgments.

1. Introduction to Model Systems in Drug Discovery (Kevin
Fitzgerald and Pamela M. Carroll).

2. Growing Yeast for Fun and Profit: Use of Saccharomyces
cerevisiae as a Model System in Drug Discovery (Petra
Ross-Macdonald).

3. Caenorhabditis elegans Functional Genomics in Drug
Discovery: Expanding Paradigms (Titus Kaletta, Lynn Butler and
Thierry Bogaert).

4. Drosophila as a Tool for Drug Discovery (Hao Li and
Dan Garza).

5. Drosophila - a Model System for Targets and Lead
Identification in Cancer and Metabolic Disorders (Corina
Schütt, Barbara Froesch and Ernst Hafen).

6. Mechanism of Action in Model Organisms: Interfacing
Chemistry, Genetics and Genomics (Pamela M. Carroll, Kevin
Fitzgerald and Rachel Kindt).

7. Gene tics and Genomics in the Zebrafish: from Gene to
Function and Back (Stefan Schulte-Merker).

8. Lipid Metabolism and Signaling in Zebrafish (Shiu-Ying Ho,
Steven A. Farber and Michael Pack).

9. Chemical Mutagenesis in the Mouse: a Powerful Tool in Drug
Target Identification and Validation (Andreas Russ, Neil Dear,
Geert Mudde, Gabriele Stumm, Johannes Grosse, Andreas
Schröder, Reinhard Sedlmeier, Sigrid Wattler and Michael
Nehls).

10. Saturation Screening of the Druggable Mammalian Genome
(Hector Beltrandelrio, Francis Kern, Thomas Lanthorn, Tamas
Oravecz, James Piggott, David Powell, Ramiro Ramirez-Solis, Arthur
T. Sands and Brian Zambrowicz).

Index.

"...an invaluable resource for an researcher in the academic or
private sector...essential for any graduate level course..." (Drug
Discovery Today, Vol 9(7), April 2004)

"...summarised the major organisms of use in this area together
with their relative strengths and weaknesses..." (British Society
of Cell Biology Newsletter, Summer 2004)