Cancer and Inflammation (eBook)
290 Seiten
John Wiley & Sons (Verlag)
978-0-470-85672-7 (ISBN)
host response to malignant disease shows several parallels with
inflammation and wound healing. The cells involved in inflammation
are detected in a range of common cancers, together with the
inflammatory cytokines and members of the chemokine ligand/receptor
systems.
Neutralization or deletion of the gene for some inflammatory
cytokines confers resistance to tumour induction and experimental
metastasis. Over-expression of such cytokines in tumour cells may
enhance malignant potential. Certain chemokines are likely to
subvert antitumour immunity by favouring development of ineffective
Type 2 responses. Tumour cells may even utilize chemokine receptors
in homing to lymph nodes and other organs. Thus, the cells,
cytokines and chemokines found in tumours are more likely to
contribute to tumour growth, progression and immunosuppression than
they are to mount an effective host antitumour response.
This book draws together contributions from an international group
of scientists and clinicians from diverse disciplines, ranging from
epidemiology to immunology, cell biology, molecular oncology,
molecular medicine and pharmacology to debate these and related
issues. Topics covered include the epidemiological links between
cancer and inflammation, the parallels between inflammation and
cancer, the role of inflammation in cancer, inflammatory genes as
risk factors for cancer initiation and progression, inflammation
and cancer angiogenesis, and preventative and therapeutic
strategies.
Related Novartis Foundation symposia:
252 Generation and Effector Functions of Regulatory
Lymphocytes
Chair: Jean-François Bach
254 Immunoinformatics: Bioinformatic Strategies for Better
Understanding of Immune Function
Chair: Hans-Georg Rammensee
The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chair: SIAMON GORDON, Sir William Dunn School of Pathology, University of Oxford, UK
Chair's Introduction (S. Gordon).
Inflammation and cancer: an epidemiological perspective (M.
Thun, et al.).
Chemokine-based pathogenetic mechanisms in cancer (I. Conti, et
al.).
General Discussion I.
Anti-TNF therapy of rheumatoid arthritis: what can we learn
about chronic disease? (M. Feldmann, et al.).
How do chemokine/chemokine receptor activations affect
tumorigenesis? (A. Richmond, et al.).
Proinflammatory cytokines, immune response and tumour
progression (M. Spadaro and G. Forni).
General discussion II.
Lymphangiogenesis and tumour metastasis (J. Tille, et al.).
Infiltration of tumours by macrophages and dendritic cells:
tumour-associated macrophages as a paradigm for polarized M2
mononuclear phagocytes (A. Mantovani, et al.).
The influence of CD25¯+ cells on the generation
of immunity to tumour cell-lines in mice (E. Jones, et al.).
Macrophages: modulators of breast cancer progression (E. Lin and
J. Pollard).
Chemokines: angiogenesis and metastases in lung cancer (R.
Strieter, et al.).
Macrophage infiltration and angiogenesis in human malignancy (H.
Knowles, et al.).
The role of inflammation for tumour growth and tumour
suppression (T. Blankenstein).
Cyclooxygenase 2: from inflammation to carcinogenesis (A.
Ristimäki).
The inflammatory cytokine network of epithelial cancer:
therapeutic implications (P. Szlosarek and F. Balkwill).
In vivo manipulation of DC migration and activation to
elicit anti-tumour immunity (A. Vicari, et al.).
Final general discussion.
Concluding remarks (S. Gordon).
Index of contributors.
Subject Index.
"This book...is highly informative, very up-to-date, and
demonstrates the complex biochemical events that may result in
carcinogenesis." (Doody's Electronic Journal)
"...a useful guide to the considered thoughts of those
within their field." (The Newsletter of the British Society
of Cell Biology, Summer 2005)
Erscheint lt. Verlag | 25.6.2004 |
---|---|
Reihe/Serie | Novartis Foundation Symposium |
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete |
Naturwissenschaften ► Biologie ► Mikrobiologie / Immunologie | |
Technik | |
Schlagworte | Biowissenschaften • Cell & Molecular Biology • Entzündung • Entzündung • Immunologie • immunology • Krebs (Medizin) • Life Sciences • Medical Science • Medizin • Oncology & Radiotherapy • Onkologie u. Strahlentherapie • Zell- u. Molekularbiologie |
ISBN-10 | 0-470-85672-6 / 0470856726 |
ISBN-13 | 978-0-470-85672-7 / 9780470856727 |
Haben Sie eine Frage zum Produkt? |
Größe: 2,6 MB
Kopierschutz: Adobe-DRM
Adobe-DRM ist ein Kopierschutz, der das eBook vor Mißbrauch schützen soll. Dabei wird das eBook bereits beim Download auf Ihre persönliche Adobe-ID autorisiert. Lesen können Sie das eBook dann nur auf den Geräten, welche ebenfalls auf Ihre Adobe-ID registriert sind.
Details zum Adobe-DRM
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen eine
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen eine
Geräteliste und zusätzliche Hinweise
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich