Immune Dysfunction and Immunotherapy in Heart Disease (eBook)

Dr. Larson and Dr. Watson have worked together researching the role of immune and cytokine dysfunction in heart disease for 8 years. They have been and currently are funded to do such research by grants from the U.S. National Institute of Heart, Lung and Blood, the American Heart Foundation, companies and private foundations. Dr. Watson has edited 62 scientific books, including several dealing with heart disease and conditions such as aging and AIDS that promote immune dysfunction as well as heart disease. Dr. Larson directs the Center's organ perfusion program as well as its Master degree in pharmacology and toxicology for perfusion students. ____________________________________________________________________ Ronald Ross Watson Ph.D. Professor Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245155, 1501 N. Campbell Avenue, Tucson, AZ 85749. (520) 626 2850, Fax (520) 626 6093 rwatson@u.arizona.edu ____________________________________________________________________ Douglas F. Larson Ph.D. Professor Surgery and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245066, 1501 N. Campbell Avenue, Tucson, AZ 85749. (520) 626 6494 dflarson@email.arizona.edu

PART 1: Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes.

01 Immunosuppression by Ultraviolet Light-B Radiation: a Mediator of Cardiac Remodeling.

02 Immune Mechanisms In Pediatric Cardiovascular Disease.

03 Heart failure - role of autoimmunity.

04 Immune basis of Hypertension in Humans.

05 Immune Dysregulation: Potential Mediator of Metabolic Syndrome-Induced Cardiac Remodeling.

06 T-Helper 2 Cell Cytokines In Remodelling Of Aortic Wall.

07 Effects of TNF-alpha on Cardiac Function.

08 Immunosuppression in Promotion of Cardiac Allograft Vasculopathy.

09 Immunotherapy for left ventricular dysfunction after heart transplantation.

PART 2: Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs.

10 Immunmodulating therapy in chronic heart failure.

11 Statins in Atherosclerosis: Role of Immune Regulation.

12 ACE Inhibitors as Immunmodulators: Treatment of Cardiovascular Disease.

13 Treatment of Heart Failure by Anticytokine Therapies.

PART 3: Immune Dysfunction Leading to Heart Dysfunction: Induction or prevention by Cardiotherapeutic Drugs.

14 Pathogenesis Of Cardiovascular Complications In The Acquired Immunodeficiency Syndrome.

15 Cytokines and T cell-Mediated Responses in Autoimmune Myocarditis.

16 Drugs of abuse: Accentuation of immunomodulation of viral myocarditis.

PART 4: Immune Dysfunction Leading to Heart Disease: Induction by Pathogens.

17 Osteopontin: The link between the Immune System and cardiac remodeling.

18 Inflammatory immune activation in heart failure patients;
Therapeutic implications.

19 Role of Innate Immune Dysregulation in Diabetic Heart Failure.

20 Tolerance in Heart Transplantation: Current and Future Role.

21 Neutralization of Th2 cytokines in therapy of cardiovascular pathology.

22 Anti-inflammatory immune therapy in heart disease.

23 Cholesterol Synthesis, Interleukin 6 inflammation and Atherosclerosis -
Role of statins, bisphosphonates and plant polyphenols in Atherosclerosis and other diseases of Aging.

24 Autoimmune myocarditis. Treatment with anti-T-cell antibodies.

25 Immunosuppressive Therapy To Counter Cardiac Allograft Vasculopathy.

26 Immunosuppression by Ultraviolet Light-B Radiation: a Mediator of Cardiac Remodeling.

27 Role of oral pathogens in the pathogenesis of coronary heart disease.

28 Myocardial regenerative potential by stem cell transplant.

29 Bioflavanoids and Dietary Anti-Inflammatory Actions: Role in Cardiovascular Diseases