Drug Discovery in Africa (eBook)

Overview of Current Drug Discovery Activities in Africa and Their Links to International Efforts to Combat Tropical Infectious Diseases.- The National Cancer Institute and Natural Product Based Drug Discovery in Africa.- Tuberculosis Drug Discovery: Target Identification and Validation.- Targeting Conserved Pathways as a Strategy for Novel Drug Development: Disabling the Cellular Stress Response.- Natural Product-Based Drug Discovery in Africa: The Need for Integration into Modern Drug-Discovery Paradigms.- Searching for Drugs that Target Multiple Receptors for Anthelmintics from African Natural Products.- Application of in silico, in vitro and in vivo ADMET/PK Platforms in Drug Discovery.- Marine Bioprospecting in Southern Africa.- Natural Products-Based Drug Discovery against Neglected Diseases with Special Reference to African Natural Resources.- ‘Now I heal with pride’ - The Application of Screens-to-Nature (STN) Technology to Indigenous Knowledge Systems Research in Botswana: Implications for Drug Discovery.- Innovative Approaches to Exploiting Traditional Medicines in Malaria.- Anticancer Drug Repositioning against Tropical Diseases: The Example of Methotrexate in the Treatment of Malaria.- Tackling the Problem of Antimalarial Resistance.- Random and Rational Approaches to HIV Drug Discovery in Africa.- Structure-Based Design of Domain-Selective Angiotensin-Converting Enzyme Inhibitors.- Natural Products and Antimalarial Drugs. Will Africa Provide the Next Major Breakthrough?.- Nanomedicine in the Development of Drugs for Poverty Related Diseases.