Uremic Toxins (eBook)
400 Seiten
John Wiley & Sons (Verlag)
978-1-118-42410-0 (ISBN)
findings
With contributions from leading international experts in the
field, this book is dedicated to all facets of uremic toxins
research, including low molecular weight solutes, protein-bound
solutes, and middle molecules. Moreover, it covers everything from
basic mass spectrometry research to the latest clinical findings
and practices.
Uremic Toxins is divided into three sections:
* Section One, Uremic Toxins, explores the definition,
classification, listing, and mass spectrometric analysis of uremic
toxins
* Section Two, Selected Uremic Toxins, describes key
uremic toxins, explaining chemical structures, metabolism,
analytical methods, plasma levels, toxicity, clinical implications,
and removal methods. Among the uremic toxins covered are indoxyl
sulfate, asymmetric dimethylarginine, PTH, ß2-microglobulin,
and AGEs
* Section Three, Therapeutic Removal of Uremic Toxins,
describes how uremic toxins can be removed by hemodialysis,
peritoneal dialysis, and oral sorbent
All chapters are based on the authors' thorough review of the
literature as well as their own personal laboratory and clinical
experience. References at the end of each chapter provide a gateway
to the literature in the field.
Reviewing all the latest basic and clinical research findings,
Uremic Toxins will help bench scientists in nephrology
advance their own investigations. It will also help clinicians take
advantage of the latest tested and proven treatments for the
management of chronic kidney disease.
TOSHIMITSU NIWA, MD, PhD, is Professor in the Department of Advanced Medicine for Uremia at the Nagoya University Graduate School of Medicine. President of the Japanese Society for Biomedical Mass Spectrometry, Dr. Niwa has received many honors for his research, including the Kimoto Prize of the Japanese Society for Dialysis Therapy and the International Society of Uremia Research and Toxicity Award. He has published more than 300 articles in peer-reviewed journals.
PREFACE ix
CONTRIBUTORS xi
SECTION 1: UREMIC TOXINS 1
1. Uremic Toxins: An Integrated Overview of Definition and
Classification 3
Richard J. Glassock and Shaul G. Massry
2. Classification and a List of Uremic Toxins 13
Nathalie Neirynck, Rita De Smet, Eva Schepers, Raymond
Vanholder, and Griet Glorieux
3. Analysis of Uremic Toxins with Mass Spectrometry 35
Toshimitsu Niwa
SECTION 2: SELECTED UREMIC TOXINS 51
4. Indoxyl Sulfate 53
Toshimitsu Niwa
5. p-Cresyl Sulfate 77
Anneleen Pletinck, Raymond Vanholder, and Griet Glorieux
6. 3-Carboxy-4-methyl-5-propyl-2-furanpropionic Acid 87
Toshimitsu Niwa
7. Phenylacetic Acid 99
Anna Schulz and Joachim Jankowski
8. Homocysteine and Hydrogen Sulfide, Two Opposing Aspects in
the Pathobiology of Sulfur Compounds in Chronic Renal Failure
109
Alessandra F. Perna and Diego Ingrosso
9. Guanidino Compounds 125
Sunny Eloot, Griet Glorieux, Peter Paul De Deyn, and Raymond
Vanholder
10. Asymmetric Dimethylarginine 143
Vladimyr Teplan and Jaroslav Racek
11. Nicotinamide Metabolites 163
Boleslaw Rutkowski and Przemyslaw Rutkowski
12. Dicarbonyls (Glyoxal, Methylglyoxal, and 3-Deoxyglucosone)
177
Naila Rabbani and Paul J. Thornalley
13. Glucose Degradation Products in Peritoneal Dialysis
193
Monika Pischetsrieder and Sabrina Gensberger
14. Dinucleoside Polyphosphates 209
Joachim Jankowski and Vera Jankowski
15. Parathyroid Hormone 227
Shaul G. Massry and Miroslaw Smogorzewski
16. b2-Microglobulin 249
Suguru Yamamoto, Junichiro James Kazama, Hiroki Maruyama, Ichiei
Narita, and Fumitake Gejyo
17. Cytokines 259
BjEURorn Anderstam, Bengt Lindholm, and Peter
Stenvinkel
18. Free Immunoglobulin Light Chains 279
Gerald Cohen and Walter H. HEURorl
19. Advanced Glycation Endproducts (AGEs) 293
Naila Rabbani and Paul J. Thornalley
20. Oxidized Albumin 305
Maurizio Bruschi, Giovanni Candiano, Laura Santucci, and Gian
Marco Ghiggeri
SECTION 3: THERAPEUTIC REMOVAL OF UREMIC TOXINS 315
21. Therapeutic Removal of Uremic Toxins by Hemodialysis
317
Tammy L. Sirich, Pavel Aronov, and Timothy W. Meyer
22. Therapeutic Removal of Uremic Toxins by Peritoneal Dialysis
331
Malgorzata Debowska, Elvia Garcya-Lopez, Jacek Waniewski, and
Bengt Lindholm
23. Therapeutic Removal of Uremic Toxins by Oral Sorbent
359
Toshimitsu Niwa
INDEX 373
| Erscheint lt. Verlag | 4.9.2012 |
|---|---|
| Reihe/Serie | Wiley-Interscience Series on Mass Spectrometry | Wiley-Interscience Series on Mass Spectrometry |
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Urologie |
| Naturwissenschaften ► Biologie ► Biochemie | |
| Naturwissenschaften ► Chemie ► Analytische Chemie | |
| Schlagworte | Biowissenschaften • Chemie • Chemistry • Life Sciences • Massenspektrometrie • Mass Spectrometry • Medical Science • Medizin • Nephrologie • Nephrology • Proteine u. Makromoleküle • Proteine u. Makromoleküle • Proteins & Macromolecules |
| ISBN-10 | 1-118-42410-7 / 1118424107 |
| ISBN-13 | 978-1-118-42410-0 / 9781118424100 |
| Haben Sie eine Frage zum Produkt? |
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