Oral Precancer (eBook)

Peter Thomson is Professor of Oral and Maxillofacial Surgery at Newcastle University and Honorary Consultant in Oral and Maxillofacial Surgery at Newcastle upon Tyne Hospitals NHS Foundation Trust. In recognition of his research into oral cancer & precancer, he has been awarded both a Hunterian Professorship from the Royal College of Surgeons of England & a King James IV Professorship from the Royal College of Surgeons in Edinburgh.

List of Contributors

Preface

Acknowledgements

1. Introduction

General Introduction

Epidemiology

Prevention Treatment Strategies

Terminology

Summary

References

2. Structure and Function of Oral Mucosa

Introduction

Applied Anatomy of the Oral Cavity

Function of the Oral Mucosa

The Microanatomy of Oral Mucosa

Regional Variation of Oral Mucosa

Oral Epithelial Cell Kinetics

Oral Epithelial Cell Proliferative Activity

Anatomical Site Predilection for Oral Carcinogenesis

Summary

References

3. Oral Carcinogenesis

Introduction

Oral Cancer and Precancer

The 'Progression Model' for Oral Cancer

Aetiology and Risk Factors

Patient and Risk Factor Profiling

Summary

References

4. Clinical Presentation of Oral Precancer

Introduction

Clinical Terminology

Precancerous (Premalignant) Lesions

Precancerous (Premalignant) Conditions

Multiple Lesion Disease

Summary

References

5. Diagnostic Methods

Introduction

Screening

Clinical Examination Techniques

Vital Tissue Staining

Light Based Detection Systems

Brush Biopsy and Exfoliative Cytology

Clinical Diagnosis in Practice

Summary

References

6. Pathological Aspects of Oral Precancer

Introduction

Biopsy Techniques

The Role of the Pathologist

Histopathological Features of Oral Potentially MalignantDisorders

Grading of Dysplasia

Limitations in Conventional Pathological Techniques

Summary

References

7. Management of Oral Precancer

Introduction

Risk Factor Modification

Observation versus Intervention

Medical Treatment

Surgical Treatment

Interventional Laser Surgery

Combined Treatment Modalities

Patient Follow Up and Surveillance

Summary

References

8. Clinical Outcome

Introduction

Clinical Outcome Studies

Patient Cohort Studies

Definitions of Clinical Outcome

Newcastle Patient Cohort Studies

Patient Follow Up

Prediction of Clinical Outcome

Summary

References

9. Malignant Transformation and Oral Cancer Development

Introduction

The Risk of Progression to Oral Carcinoma

Malignant Transformation versus Oral Cancer Development

Interventional Laser Surgery and Oral Cancer Prevention

The Newcastle 10 Year Follow Up Study

High and Low Risk Patients

Clinical Signs of Oral Squamous Cell Carcinoma

Diagnosis and Management of 'UnexpectedMalignancy'

Prognosis for the 'Transformed Patient'

Summary

References

10. The Future

Introduction

Prevention of Oral Precancer

Early Diagnosis of Potentially Malignant Disease

Interventional Management Strategies in the Future

Individualised Patient Treatments - Biomarkers andTargeted Chemoprevention

Future Research Directions

Summary

References

11. Case Histories

Introduction

Diagnosis of Unexpected Malignancy

Multiple Lesion Disease Responding to ConservativeManagement

Multiple Lesion Disease Requiring Repeated Laser Treatments

Proliferative Verrucous Leukoplakia

Localised Oral Lichenoid Reaction

Multiple Oral Lichenoid Reactions

Widespread Dysplastic Oral Lichenoid Reactions

An Immunosuppressed Patient

Chronic Hyperplastic Candidosis

Tobacco Associated Hyperkeratosis

Malignant Transformation in Longstanding Non-erosive LichenPlanus

Summary

12. Conclusions

Oral Cancer Potentially Malignant Disorders

Clinical Management

Patient Care Pathways

Public Health Strategies

Future Directions

Index

"I would highly recommend the book for those wishing to
expand their knowledge on oral malignancy at a specialist trainee
or higher level." (British Dental Journal, 12
October 2013)