Rapid Clinical Pharmacology (eBook)

Andrew Batchelder is an Academic doctor at University Hospitals of Leicester (UHL). Charlene Rodrigues is an Academic doctor at the London Deanery. Ziad Alrifai is an Academic doctor at University Hospitals of Leicester (UHL). Adrian Stanley is a Consultant Physician in Cardiovascular Medicine and Honorary Senior Lecturer (Medical Education), UHL.

Preface, ix

List of abbreviations, xi

Basic pharmacokinetic concepts

Gastrointestinal system

Histamine type 2 receptor antagonists, 5

Laxatives, 6

Proton pump inhibitors (PPIs), 7

Cardiovascular system

a-adrenoceptor antagonists (a blockers), 8

Adenosine, 9

Aldosterone antagonists, 10

Amiodarone, 11

Angiotensin-converting enzyme inhibitors (ACEIs), 12

Angiotensin II receptor blockers (ARBs), 13

Antimuscarinics, 14

Aspirin, 15

b-adrenoceptor antagonists (b blockers), 16

Calcium channel blockers (CCBs), 18

Cardiac glycosides, 19

Clopidogrel, 20

Dipyridamole, 21

Fibrates, 22

Fibrinolytics, 23

Flecainide, 24

Glycoprotein IIb/IIIa inhibitors, 25

Inotropic sympathomimetics, 26

Loop diuretics, 27

Low molecular weight heparins (LMWH), 28

Nitrates, 29

Potassium channel activators, 30

Statins, 31

Thiazide diuretics, 32

Tranexamic acid, 33

Vasoconstrictor sympathomimetics, 34

Warfarin, 35

Respiratory system

b2 adrenoceptor agonists, 36

Histamine type 1 receptor antagonists, 37

Inhaled antimuscarinics, 38

Leukotriene receptor antagonists, 39

Oxygen, 40

Theophylline, 41

Central nervous system

5-HT1 agonists (triptans), 42

5-HT3 antagonists, 43

Antihistamine anti-emetics, 44

Antipsychotics - atypical, 45

Antipsychotics - typical, 46

Benzodiazepines, 47

Carbamazepine, 48

Dopamine antagonist anti-emetics, 49

Drugs for dementia, 50

Gabapentin and pregabalin, 51

Levodopa (L-dopa), 52

Lithium, 53

Monoamine oxidase inhibitors (MAOIs), 54

Non-steroidal anti-inflammatory drugs (NSAIDs), 55

Opioid analgesia, 56

Other antiepileptics, 57

Other antiparkinsonian drugs, 58

Paracetamol, 59

Phenothiazine anti-emetics, 60

Phenytoin, 61

Selective serotonin reuptake inhibitors (SSRIs), 62

Sodium valproate, 63

Tricyclic antidepressants (TCAs), 64

Infections

Aciclovir, 65

Aminoglycosides, 66

Antifungals, 67

Antiretroviral agents, 68

Antituberculosis drugs, 69

Cephalosporins and other b lactams, 70

Penicillins, 71

Glycopeptide antibiotics, 72

Macrolides, 73

Metronidazole, 74

Nitrofurantoin, 75

Quinolones, 76

Tetracyclines, 77

Trimethoprim, 78

Endocrine system

5a-reductase inhibitors, 79

Antidiuretic hormone (ADH) analogues, 80

Biguanides, 81

Bisphosphonates, 82

Carbimazole, 83

Corticosteroids, 84

Dipeptidylpeptidase-4 (DDP-4) inhibitors, 85

Gonadotrophin-releasing hormone (GnRH) agonists, 86

Hormone replacement therapy (HRT), 87

Incretin mimetics, 88

Insulins, 89

Levothyroxine, 90

Propylthiouracil, 91

Sulfonylureas, 92

Thiazolidinediones, 93

Obstetrics, gynaecology and urinary tract disorders

Contraceptives, 94

Mifepristone, 96

Oxybutynin, 97

Oxytocin, 98

Phosphodiesterase type 5 inhibitors, 99

Malignant disease and immunosuppression

Alkylating agents, 100

Anthracyclines, 101

Anti-androgens, 102

Antimetabolites, 103

Antiproliferative immunosuppressants, 104

Calcineurin inhibitors, 105

Other antineoplastic drugs, 106

Selective oestrogen receptor modulators (SERMs), 107

Trastuzumab (Herceptin), 108

Vinca alkaloids, 109

Musculoskeletal and joint diseases

Allopurinol, 110

Aminosalicylic acid compounds (ASAs), 111

Colchicine, 112

Methotrexate, 113

Contents vii

Eye

Antiglaucoma drugs, 114

Anaesthesia

Depolarising neuromuscular blocking agents, 115

Etomidate, 116

Inhalational anaesthetics, 117

Lidocaine, 118

Non-depolarising blocking agents, 119

Propofol, 120

Thiopental sodium, 121

Intravenous fluids

Blood and transfusion medicine

Index of drugs, 127

"This is an excellent pocket manual on core drugs for medical
practitioners, especially those practicing in a British-oriented
healthcare system." (Doody's, 13 January 2012)



"The book is practical and made more so by its availability for
mobile electronic devices such as iPhones, iPad, and so on. This
book represents an important step in application of medical
knowledge and technology by the bed side." (Journal of Tropical
Pediatrics, 1 November 2011)