Chemical Biology (eBook)

NATANYA CIVJAN, PhD, is a freelance editor with a doctorate in biochemistry. Formerly with John Wiley & Sons, she developed and edited the Wiley Encyclopedia of Chemical Biology and was part of the team responsible for the Wiley Interdisciplinary Reviews, which won top prizes in publishing from the American Publishers Awards for Professional and Scholarly Excellence.

Contributors xi

PART I DRUG DISCOVERY AND DEVELOPMENT 1

1 The Role of Chemical Biology in Drug Discovery 3

Andrew J. Pope

2 Computational Approaches to Drug Discovery and Development
23

Honglin Li, Mingyue Zheng, Xiaomin Luo, Weiliang Zhu, and
Hualiang Jiang

3 Design and Selection of Small Molecule Inhibitors 41

Jianwei Che, Yi Liu, and Nathanael S. Gray

4 Lead Optimization in Drug Discovery 65

Craig W. Lindsley, David Weaver, Thomas M. Bridges, and J.
Phillip Kennedy

5 Pharmacokinetics of Drug Candidates 83

Ronald E. White

6 ADME Properties of Drugs 101

Li Di and Edward H. Kerns

7 Drug Transport in Living Systems 115

Yael Elbaz and Shimon Schuldiner

8 Blood-Brain Barrier: Considerations in Drug Development and
Delivery 133

David S. Miller and Brian T. Hawkins

9 Pharmacokinetic Considerations: Methods and Systems of
Controlled Drug Delivery 147

Zhong Zuo and Vincent H. L. Lee

10 Pharmaceuticals: Natural Products and Natural Product Models
165

Sheo B. Singh

PART II CHEMICAL BIOLOGY TO UNDERSTAND AND TARGET DISEASE
203

11 The Role of Chemical Biology in Understanding and
Treating

Disease--Are Small Molecule "Correctors" the Way
of the Future? 205

David Selwood

12 Anxiety Disorders 215

Miklos Toth

13 Chronic Obstructive Pulmonary Disease (COPD) 245

Peter J. Barnes

14 Depression 267

Glen B. Baker and Nicholas D. Mitchell

15 Osteoarthritis 293

Marjolaine Gosset, Jeremie Sellam, Claire Jacques, nd Francis
Berenbaum

16 Human Immunodeficiency Virus (HIV) 331

Joseph P. Vacca

17 Allergy and Asthma 341

Garry M. Walsh

18 Schizophrenia 357

Ferenc Martenyi

19 Protein Misfolding and Disease 379

Johanna C. Scheinost, Grant E. Boldt, and Paul Wentworth

20 Protein Trafficking Diseases 401

Heidi M. Sampson and David Y. Thomas

21 Metabolic Diseases 419

Cynthia M. Arbeeny

22 Mitochondrial Medicine 445

Richard J. T. Rodenburg and Jan A. M. Smeitink

23 Lysosomal Disorders 461

Doug A. Brooks and Maria Fuller

Index 483