Chemical Biology (eBook)
524 Seiten
John Wiley & Sons (Verlag)
978-1-118-43450-5 (ISBN)
biology in drug discovery and development
Based on the award-winning Wiley Encyclopedia of Chemical
Biology published in 2008, this book explores the role of
chemical biology in drug discovery and development. The first part
of the book reviews key principles and techniques used in the
design and evaluation of drug candidates. The second part
elucidates biological mechanisms of certain diseases, illuminating
approaches to investigate and target these diseases.
Comprising carefully selected reprints from the
Encyclopedia as well as new contributions from leading
scholars in the field, this book provides researchers in academia
and industry with important information to aid in the development
of novel agents to treat disease. Self-contained articles cover a
variety of essential topics, including:
* The design, development, and optimization of drug
candidates
* The pharmacokinetics and properties of drugs
* Drug transport and delivery
* Natural products and natural product models as
pharmaceuticals
* Biological mechanisms underlying health and disease
* Treatment strategies for a range of diseases, from HIV to
schizophrenia
Chemical Biology is a top-notch guide and reference for
anyone working in the areas of drug discovery and development,
including researchers in chemical biology and other fields such as
biochemistry, medicine, and pharmaceutical sciences.
NATANYA CIVJAN, PhD, is a freelance editor with a doctorate in biochemistry. Formerly with John Wiley & Sons, she developed and edited the Wiley Encyclopedia of Chemical Biology and was part of the team responsible for the Wiley Interdisciplinary Reviews, which won top prizes in publishing from the American Publishers Awards for Professional and Scholarly Excellence.
Contributors xi
PART I DRUG DISCOVERY AND DEVELOPMENT 1
1 The Role of Chemical Biology in Drug Discovery 3
Andrew J. Pope
2 Computational Approaches to Drug Discovery and Development
23
Honglin Li, Mingyue Zheng, Xiaomin Luo, Weiliang Zhu, and
Hualiang Jiang
3 Design and Selection of Small Molecule Inhibitors 41
Jianwei Che, Yi Liu, and Nathanael S. Gray
4 Lead Optimization in Drug Discovery 65
Craig W. Lindsley, David Weaver, Thomas M. Bridges, and J.
Phillip Kennedy
5 Pharmacokinetics of Drug Candidates 83
Ronald E. White
6 ADME Properties of Drugs 101
Li Di and Edward H. Kerns
7 Drug Transport in Living Systems 115
Yael Elbaz and Shimon Schuldiner
8 Blood-Brain Barrier: Considerations in Drug Development and
Delivery 133
David S. Miller and Brian T. Hawkins
9 Pharmacokinetic Considerations: Methods and Systems of
Controlled Drug Delivery 147
Zhong Zuo and Vincent H. L. Lee
10 Pharmaceuticals: Natural Products and Natural Product Models
165
Sheo B. Singh
PART II CHEMICAL BIOLOGY TO UNDERSTAND AND TARGET DISEASE
203
11 The Role of Chemical Biology in Understanding and
Treating
Disease--Are Small Molecule "Correctors" the Way
of the Future? 205
David Selwood
12 Anxiety Disorders 215
Miklos Toth
13 Chronic Obstructive Pulmonary Disease (COPD) 245
Peter J. Barnes
14 Depression 267
Glen B. Baker and Nicholas D. Mitchell
15 Osteoarthritis 293
Marjolaine Gosset, Jeremie Sellam, Claire Jacques, nd Francis
Berenbaum
16 Human Immunodeficiency Virus (HIV) 331
Joseph P. Vacca
17 Allergy and Asthma 341
Garry M. Walsh
18 Schizophrenia 357
Ferenc Martenyi
19 Protein Misfolding and Disease 379
Johanna C. Scheinost, Grant E. Boldt, and Paul Wentworth
20 Protein Trafficking Diseases 401
Heidi M. Sampson and David Y. Thomas
21 Metabolic Diseases 419
Cynthia M. Arbeeny
22 Mitochondrial Medicine 445
Richard J. T. Rodenburg and Jan A. M. Smeitink
23 Lysosomal Disorders 461
Doug A. Brooks and Maria Fuller
Index 483
| Erscheint lt. Verlag | 7.8.2012 |
|---|---|
| Sprache | englisch |
| Themenwelt | Medizin / Pharmazie ► Gesundheitsfachberufe |
| Medizin / Pharmazie ► Medizinische Fachgebiete ► Pharmakologie / Pharmakotherapie | |
| Naturwissenschaften ► Biologie | |
| Naturwissenschaften ► Chemie ► Organische Chemie | |
| Technik | |
| Schlagworte | Biochemie • Biochemie u. Chemische Biologie • Biochemistry (Chemical Biology) • Chemie • Chemische Biologie • Chemistry • Medical Science • Medizin • Pharmaceutical & Medicinal Chemistry • Pharmacology & Pharmaceutical Medicine • Pharmakologie u. Pharmazeutische Medizin • Pharmazeutische u. Medizinische Chemie |
| ISBN-10 | 1-118-43450-1 / 1118434501 |
| ISBN-13 | 978-1-118-43450-5 / 9781118434505 |
| Haben Sie eine Frage zum Produkt? |
EPUB (Adobe DRM)Größe: 13,8 MB
Kopierschutz: Adobe-DRM
Adobe-DRM ist ein Kopierschutz, der das eBook vor Mißbrauch schützen soll. Dabei wird das eBook bereits beim Download auf Ihre persönliche Adobe-ID autorisiert. Lesen können Sie das eBook dann nur auf den Geräten, welche ebenfalls auf Ihre Adobe-ID registriert sind.
Details zum Adobe-DRM
Dateiformat: EPUB (Electronic Publication)
EPUB ist ein offener Standard für eBooks und eignet sich besonders zur Darstellung von Belletristik und Sachbüchern. Der Fließtext wird dynamisch an die Display- und Schriftgröße angepasst. Auch für mobile Lesegeräte ist EPUB daher gut geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen eine
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen eine
Geräteliste und zusätzliche Hinweise
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich
