Irritable Bowel Syndrome – Diagnosis and Clinical Management

Anton Emmanuel is Consultant Gastroenterologist at University College Hospital, London and one of the rising stars of the UK gastroenterology scene. His clinical work encompasses being director of the GI Physiology Unit at University College Hospital as well as providing a general gastroenterology service. His research includes basic gut neurophysiology and the study of the aetiology and management of functional gastrointestinal disorders of the upper and lower gut. He currently supervises 9 post-graduate research fellows undertaking higher degrees. Laboratory work is undertaken jointly with colleagues in UCL, Imperial College and industry. He is the Secretary of the NeuroGastroenterology section of the British Society of Gastroenterology. Eamonn Quigley is Professor of Medicine and Human Physiology, University College Cork, Cork, Ireland He has formerly been Professor of Medicine and Physiology and Chief of gastroenterology and hepatology at the University of Nebraska Medical Centre (UNMC). There he developed there a clinical research centre for the study of gastrointestinal motility and pursued parallel studies in a variety of in vitro and in vivo animal models. In 1998, Prof. Quigley on returning to Cork as Professor of Medicine and Human Physiology he was the first Head of the Medical School from 2000-7. He is a principal investigator in the Alimentary Pharmabiotic Centre (APC), funded by Science Foundation Ireland (SFI) in 2003 and again in 2009 where his interests are in host-microbiota interactions in gastrointestinal disorders. Prof. Quigley is Vice President of the American College of Gastroenterology and a past Editor-in-Chief of the American Journal of Gastroenterology. He has published over 500 original articles, reviews, editorials, book chapters; authored or co-authored six books and monographs. He has received a variety of honours and awards from medical and gastroenterological societies and universities throughout the world.

List of Contributors, vii Foreword, ix Preface, xi Part 1 Overview of Irritable Bowel Syndrome, 1 1 Definitions and Classifications of Irritable Bowel Syndrome, 3 Alexander C. Ford 2 Epidemiology of Irritable Bowel Syndrome, 23 Stefan Muller-Lissner 3 Global Impact of Irritable Bowel Syndrome, 37 Eamonn M.M. Quigley Part 2 Diagnosis of Irritable Bowel Syndrome, 51 4 What is the Best Way to Identify and Quantify Irritable Bowel Syndrome?, 53 Gururaj J. Kolar and G. Richard Locke, III 5 Practical Approach to Clinical Assessment of Irritable Bowel Syndrome, 69 Robin Spiller and Ching Lam 6 Interface between Primary Care and Secondary Care, 93 Nicholas S. Coleman and Hazel Everitt Part 3 Symptom-specific Treatment of IrritableBowel Syndrome, 119 7 Self-Management Strategies for Irritable Bowel Syndrome, 121 Monica E. Jarrett, Pamela Barney and Margaret M. Heitkemper 8 Food-related Symptoms of Irritable Bowel Syndrome, 141 Michel Dapoigny 9 Gut Inflammation in Irritable Bowel Syndrome, 159 Kok-Ann Gwee 10 Psychological Factors and Treatments in Irritable Bowel Syndrome, 183 Stephan R. Weinland and Douglas A. Drossman 11 Gut Motility Related Symptoms, 215 Juan-R. Malagelada and Carolina Malagelada 12 Gut Hypersensitivity Related Symptoms, 237 Adam D. Farmer, Madusha Peiris and Qasim Aziz 13 Abdominal Bloating, 263 Peter J. Whorwell 14 Sequencing the Treatments: The Book in One Chapter!, 277 Hans Tornblom and Magnus Simren Part 4 What s next in Irritable Bowel Syndrome, 301 15 Diagnostic and Therapeutic Horizons for Irritable Bowel Syndrome, 303 Jan Tack Index, 315