Clinical Interest of Steroid Hormone Receptors in Breast Cancer

I. Receptor Assays.- Classical Methods.- Sampling and Storage of Breast Cancer Tissue for Steroid Receptor Assays.- Routine Assays for Steroid Hormone Receptors.- Mathematical Analysis of Data from Receptor Assays.- New Methods.- Estrogen and Progestin Receptor Analysis in Human Breast Cancer by Isoelectric Focusing in Slabs of Polyacrylamide Gel.- Estrogen Receptor Analysis on Fine Needle Aspirates from Human Breast Carcinoma.- Estrogen and Progestin Receptors on Drill Biopsy Samples of Human Mammary Tumors.- The Value of Determination of Nuclear Oestrogen Receptors in Breast Cancer Biopsies.- Histochemical Methods.- Immunocytochemical Demonstration of Steroid Receptors.- Use of Fluorescent Sex-Steroid Conjugates for the Histochemical Detection of Breast Cancer Cell Receptors: A Critique.- Microscopic Visualization of Steroid Receptor Sites: A Mirage?.- I: A Critical Summary 86 R. J. B. King.- II. Quality Control.- Quality Control of Estrogen and Progesterone Receptor Analyses in Denmark.- Results of External Quality Control Trials Performed by the German Cooperative Group for Receptor Assay Standardization.- British Interlaboratory Quality Assessment of Steroid Receptor Assays.- Quality Control Program for Estradiol Receptor Determination: The Italian Experience.- Quality Control of Steroid Receptor Assays in the Netherlands.- Quality Control of Clinical Steroid Receptor Assays in Sweden.- Interlaboratory Variability in the Determination of Estrogen Receptor and Progesterone Receptor Content in Human Breast Tumors.- Standardization of Steroid Receptor Analysis in Breast Cancer Biopsies: EORTC Receptor Group.- II: A Critical Summary 136 G. Leclercq.- III. Biology of the Primary Tumor.- Estrogen Receptors and Distribution of Prognostic Factors in Primary Breast Cancer.-Influence of Intratumoral Estradiol Biosynthesis on Estrogen Receptors.- Influence of Endogenous Hormone Levels on Tumor Estradiol and Progesterone Receptors.- Inflammatory Tumors of the Human Breast: Determination of Estrogen and Progesterone Receptors.- Relationship Between Estrogen Receptors and Cellular Proliferation.- Relationship of Stromal Elastosis to Steroid Receptors in Human Breast Carcinoma.- III: A Critical Summary 176 G. Contesso, J. C. Delarue, F. May-Levin, H. Sancho-Gamier, H. Mouriesse.- IV. The Course of Disease.- Estrogen Receptor Variations in Neoplastic Tissue During the Course of Disease in Patients with Recurrent Breast Cancer.- The Prognostic Value of Progesterone Receptors in Primary Breast Cancer.- Estrogen and Progesterone Receptors as Prognostic Factors in Early Breast Cancer.- IV: A Critical Summary 199 L. Santi.- V. Treatments.- Adjuvant Treatment.- Relationship Between Estrogen Receptors and CMF Adjuvant Chemotherapy.- New Adjuvant Trials for Resectable Breast Cancer at the Istituto Nazionale Tumori of Milan.- Effect of Adjuvant Therapy in Primary Breast Cancer in Relation to the Estrogen Receptor Level.- V: A Critical Summary.- Palliative Treatment.- Endocrine Surgery in Breast Cancer.- Treatment of Advanced Breast Cancer with Tamoxifen.- Therapeutic Activity of Medroxyprogesterone Acetate in Metastatic Breast Cancer: A Correlation Between Estrogen Receptors and Various Dosages.- Estrogen Receptor Status and the Clinical Response to a Combination of Aminoglutethimide and Cortisol in Advanced Breast Cancer.- Steroid Receptors in Megestrol Acetate Therapy.- Protocols Based on Steroid Receptors: Great Britain.- Currently Active Protocols in the EORTC Breast Cancer Cooperative Group.- The Place of Hormone Receptors in the Elaboration of a Therapeutic Strategy Against Breast Cancer.- V: A Critical Summary.- VI. Prospects for Future Tests of Hormone Dependence.- Peroxidase Activity as a Marker for Estrogen Action in Rat Uteri and Human Mammary Carcinomas.- Estrogen-Induced Proteins in Human Breast Cancer Cells.- Stimulation by 17?-Estradiol of a Secreted Glycoprotein in MCF-7 Cells and Human Breast Cancer.- Estrogen Action on the Synthesis and Secretion of a Broad Spectrum of Proteins in Mammary Tumor Cells.- VII. Laboratories Performing Receptor Assays.- Austria.- Belgium (and Luxembourg).- Denmark.- Federal Republic of Germany.- France.- Great Britain.- Ireland.- Italy.- The Netherlands.- Spain.- Sweden (and Norway).- Switzerland.