The Pituitary and Testis

1 Patterns of Secretion and Metabolism of the Gonadotrophic Hormones.- 1.1 Assay Methods.- 1.2 Patterns of LH and FSH Secretion in Normal Men.- 1.3 Metabolic Clearance and Gonadotrophin Secretion Rates in Normal Men.- 1.4 Summary.- 2 Control of FSH and LH Secretion.- 2.1 Sites of Production of FSH and LH.- 2.2 Hypothalamic Influences on FSH and LH Secretion.- 2.3 Influence of Testicular Feedback.- 2.4 Assays for Inhibin.- 2.5 Assay Specificity.- 2.6 Sources of Inhibin.- 2.7 Evidence for Inhibin from Immunisation Studies.- 2.8 Characteristics and Mode of Action of Inhibin.- 2.9 Physiological Implications of Inhibin.- 2.10 Summary.- 3 Pituitary Testicular Axis During Pubertal Development.- 3.1 Studies in Men.- 3.2 Studies in Rats.- 3.3 Studies in Rams.- 3.4 Overall Comments.- 4 Changes in the Pituitary-Testicular Axis with Age.- 4.1 Introduction.- 4.2 Methods.- 4.3 Summary of Results.- 4.4 Significance of Senescent Testicular Degeneration.- 4.5 Clinical Relevance.- 4.6 Summary.- 5 Spermatogenesis and the Sertoli Cell.- 5.1 Spermatogenesis.- 5.2 The Sertoli Cell.- 6 Leydig Cell Function.- 6.1 Introduction.- 6.2 Morphology of the Leydig Cell.- 6.3 Steroid Biosynthesis and Secretion.- 6.4 Regulation of Leydig Cell Function.- 6.5 Hormonal Regulation of LH Receptors.- 6.6 Leydig Cells and Spermatogenesis.- 6.7 Androgens in Blood.- 6.8 Abnormalities of Leydig Cell Function.- 7 The Effect of Testicular Damage on Sertoli and Leydig Cell Function.- 7.1 Introduction.- 7.2 Spermatogenic Damage and the Control of FSH Secretion.- 7.3 Sertoli Cell Function and Testicular Damage.- 7.4 Luteinising Hormone, Testosterone and Spermatogenic Damage.- 7.5 Leydig Cell Structure and Spermatogenic Damage.- 7.6 Leydig Cell Function and Testicular Damage.- References.