Adjuvant Therapies of Cancer

I. General Considerations.- 1. Metastatic Potential of Metastases, Tumor Cell Heterogeneity, and Therapeutic Implications.- 2. Immune Imbalance and Immune Modulation in Solid Tumor Patients: New Insights.- 3. Markers of Minimal Residual Disease.- 4. Radiotherapy as Adjuvant Local Therapy of Local Tumors.- II. Hemopoietic and Lymphoid Neoplasias.- 5. Comparison of HLA Phenotypes in Long-Term Survivors with Acute Lymphoblastic Leukemia Treated with Immunotherapy Versus Chemotherapy.- 6. An Intensive Chemo- or Chemoimmunotherapy Regimen for Patients with Intermediate and Poor- Prognosis Acute Lymphatic Leukemia and Leukemic Lymphoblastic Lymphosarcoma: Preliminary Results with 14-Month Median Follow-Up.- 7. Poor-Prognosis Acute Lymphoblastic Leukemias.- 8. Therapeutic Effectiveness of Neuraminidase- Treated Allogeneic Myeloblasts as Immunogen in Acute Myelocytic Leukemia.- 9. Maintenance Chemoimmunotherapy of Nonlymphoblastic Acute Leukemias.- 10. Possible Mechanisms of Immunotherapy Action in Acute Nonlymphatic Leukemia: Macrophage Production of Colony-Stimulating Activity.- 11. The Finnish Leukaemia Group: Levamisole in Maintenance Therapy of Acute Myeloid Leukemia in Adults.- 12. Treatment of Acute Leukemia in Remission by Bone Marrow Transplantation.- 13. Prevention of Blastic Crisis in Ph1 -Positive Chronic Myeloid Leukemia.- 14. A Southwest Oncology Group: Chemotherapy Versus Chemotherapy Plus Radiotherapy in Treatment of Stage III Hodgkin's Disease.- 15. Maintenance Immunotherapy with BCG in Non-Hodgkin's Malignant Lymphomas: A Progress Report of a Randomized Trial.- III. Bone Tumors.- 16. Role of Lung Irradiation in the Adjuvant Treatment of Osteosarcoma.- 17. Adjuvant Interferon Treatment of Human Osteosarcoma.- 18. A Strategic Adjuvant Therapy ofOsteosarcoma.- 19. Ewing's Sarcoma: Treatment with High-Dose Radiation and Adjuvant Chemotherapy.- 20. Adjuvant Chemotherapy in Ewing's Sarcoma Patients.- 21. Early Results of Combined Modality Therapy of Patients with Ewing's Sarcoma.- 22. Ewing's Sarcoma: 5-Year Survival Under Adjuvant Chemotherapy.- IV. Breast Carcinoma.- 23. Natural History of Breast Cancer.- 24. Adjuvant Chemotherapy in Breast Cancer.- 25. Multimodal Therapy with CMF in Resectable Breast Cancer with Positive Axillary Nodes: The Milan Institute Experience.- 26. Follow-Up Results from a Randomized Trial for T3 and T4 Breast Cancer Patients: Previous BCG Immunotherapy Improves Response to Chemotherapy in the Relapse Patient.- 27. Adjuvant Treatment of Node-Positive Breast Cancer with Adriamycin-Cyclophosphamide with or Without Radiation Therapy: Interim Results of an Ongoing Clinical Trial.- 28. A Randomized Trial of Postoperative Five- Versus Three-Drug Chemotherapy After Mastectomy: A Cancer and Leukemia Group B (CALGB) Study.- 29. Adjuvant Chemoimmunotherapy with LMF Plus BCG in Node-Negative and Node-Positive Breast Cancer - Intermediate Report at 4 Years.- 30. Adjuvant Intermittent Chemoimmunotherapy for Primary Breast Cancer: A Prospective Study with Immunologic Follow-Up.- 31. Short-Term and Long-Term Effects of Chemoimmunotherapy on Granulopoiesis: Adjuvant Therapy of Breast Cancer.- 32. A New Adjuvant Treatment with Polyadenylic- Polyuridylic Acid in Operable Breast Cancer.- V. Lung Carcinoma.- 33. Metastatic CNS Disease in Small Cell Carcinoma of the Bronchus: The Role of Radiotherapy and Chemotherapy.- 34. Interim Results of EORTC Protocol 08742: Comparison, After Irradiation of Locally Advanced Squamous Cell Bronchial Carcinoma, of Abstention, Immunotherapy, CombinationChemotherapy or Chemoimmunotherapy.- 35. Immunologically Defined Prognostic Subgroups as Predictors of Response to BCG Immunotherapy.- 36. Intrapleural BCG Immunotherapy of Lung Cancer Patients.- 37. Specific Active Immunotherapy in Lung Cancer: The Induction of Long-Lasting Cellular Responses to Tumour-Associated Antigens.- 38. Malnutrition in Lung Cancer: Incidence, Prognostic Implications, and Pathogenesis.- 39. Follow-Up of a Randomized Trial for Oat Cell Carcinoma Evaluating the Efficacy of Peripheral Intravenous Nutrition (PIVN) as Adjunct Treatment.- VI. Melanoma.- 40. Clinical Trials of Chemotherapy and Chemoimmunotherapy in Primary Malignant Melanoma.- 41. Trial 6: Randomized Study of Prolonged Chemotherapy, Immunotherapy, and Chemoimmunotherapy as an Adjuvant to Surgery for Stage I and II Melanoma. A Progress Report.- 42. Current Status of Melanoma Chemotherapy and Immunotherapy.- VII. Testicular Neoplasia.- 43. Adjuvant Therapy of Testicular Carcinoma.- VIII. Gastrointestinal Neoplasms.- 44. Adjuvant 5-Fluorouracil and BCNU Chemotherapy in Gastric Cancer: 3-Year Results.- 45. Adjuvant Chemotherapy in Colon and Gastric Cancer.- 46. Chemotherapy of Metastatic Gastrointestinal Cancers: Prospects for Future Adjuvant Systemic Therapies.- 47. Chemotherapy of Carcinomas of the Digestive Tract.- IX. Conclusions and Prospects.- 48. Clinical Trials on Adjuvant Therapies in Cancer: Short-Term and Long-Term Results.- 49. Long-Term Costs of Adjuvant Radiotherapy.- 50. Long-Term Cost of Combined Radiotherapy and Chemotherapy.- 51. Studies of Clonogenic Human Tumor Stem Cells.- 52. Current Status of Clinical Trials of m-AMSA, Dihydroxyanthracenedione, and Deoxycoformycin.- 53. Three New Agents for Immunotherapy Trials: Azimexon, Bestatin, and Tuftsin.- 54. Emerging Immunologic Approaches to Treatment of Neoplastic Diseases.- 55. Cellular Interactions Modulating Host Resistance to Tumours.- 56. Preliminary Clinical Results with Norgamen (Thioproline) and Revercan (S-Amino-2- Thiazoline): The First Inducers of Reverse Transformation.- 57. Biologic Response Modifiers and Adjuvant Chemotherapy: Consideration of Selected Preclinical Investigations in Relation to Clinical Potential.